Improving vision in keratoconus using laser collagen cross-linking

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of Optical Coherence Tomography (OCT) to guide laser custom corneal collagen cross-linking (CXL) in patients with keratoconus. By measuring corneal thickness and other parameters, the study aims to enhance the precision of the CXL procedure, which is designed to reduce corneal aberrations and improve visual outcomes. The research will evaluate the effectiveness of this approach in comparison to traditional methods, particularly focusing on the impact of using mitomycin-C during the procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of keratoconus
* Minimum corneal thickness of 410 microns

Exclusion Criteria:

* Inability to maintain fixation for OCT imaging
* Inability to commit to required study visits
* Inability to give informed consent
* Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery
* Mature cataracts if found to limit visual potential to worse than 20/40

Where it's running

• Oregon Health & Science University
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: David Huang, MD, PhD — Oregon Health and Science University
• Study coordinator: Denzil Romfh, OD
• Email: romfhd@ohsu.edu
• Phone: 503-494-4351

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Corneal Crosslinking to Treat Progressive Keratoconus or Corneal Ectasia

  This study tests two different light durations used in corneal crosslinking to see which better helps people with keratoconus or corneal ectasia.

  Recruiting Phase 2/3 Price Vision Group · Indianapolis, Indiana · NCT07841470

• Brillouin hydration mapping to study cornea health

  Researchers test a Brillouin microscope to see if it can measure corneal water content in healthy people and those with eye conditions.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07780890

• Same-day bilateral corneal cross-linking for keratoconus

  This trial tests whether performing corneal cross-linking in both eyes on the same day is safe and feasible for people with keratoconus.

  Recruiting Phase 4 Glaukos Corporation · Westerville, Ohio · NCT07629557

• A Smart Aperture Lens to Help Keratoconus and Presbyopia

  This study tests the NOA lens, a custom scleral contact lens with a central aperture, to see if it improves vision for people with keratoconus and presbyopia.

  Recruiting at 2 sites Azalea Vision · Antwerp and 1 other locations · NCT07559188

• GLK-221 eye drops for keratoconus

  This trial will test whether twice-daily GLK-221 eye drops are safe and help adults aged 18–55 with keratoconus compared with a placebo.

  Recruiting Phase 2 Glaukos Corporation · Westerville, Ohio · NCT07400952

• Corneal wavefront-guided PRK plus epi-off CXL versus PTK plus epi-off CXL for keratoconus

  This trial tests whether adding corneal wavefront-guided PRK to epi-off corneal cross-linking gives better vision than PTK plus epi-off CXL in adults with keratoconus.

  Recruiting Instituto de Oftalmología Fundación Conde de Valenciana · Mexico City, Mexico City · NCT07372911

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.