Testing Brillouin Microscopy for Diagnosing Corneal Conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the diagnostic capabilities of Brillouin microscopy in assessing corneal conditions such as keratoconus and ectasia. It involves performing axial scans of the cornea on human volunteers to compare the biomechanical properties of keratoconus and normal corneas, as well as post-LASIK ectasia versus normal corneas. The study aims to enhance diagnostic accuracy for these conditions using advanced imaging techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Group I includes healthy subjects with normal appearing corneas, normal topography and pachymetry. Group II includes patients diagnosed as having mild, moderate or advanced keratoconus by our ophthalmology expert on the basis of topography and pachymetry. Group III includes healthy subjects who have undergone LASIK surgery in the past 12 months without complications. Inclusion criteria include normal post-operative topography and pachymetry. Group IV includes patients (age 20 - 60) who have undergone LASIK surgery at least 12 months before the study imaging and have been diagnosed with post-LASIK ectasia based on topography, pachymetry and clinical evaluation.Patients diagnosed with keratoconus. Group V- Volunteers to receive PRK surgery This group includes patients who have been diagnosed with myopia and have been scheduled to undergo PRK surgery. Patients with high astigmatism \> 2 diopter, prior ocular surgeries, and those patients taking any ocular medications except seasonal allergy medicine such as ketotifen or artificial tears will be excluded. Group VI-Volunteers to receive LASIK Surgery This group includes myopic patients who are scheduled to receive LASIK surgery. Patients with high astigmatism \> 2 diopter, prior ocular surgeries, and those patients taking any ocular medications except seasonal allergy medicine such as ketotifen and artificial tears will be excluded. Group VII- Patients with Fuch's Endothelial Corneal Dystrophy. This group includes subjects who are diagnosed with Fuch's corneal dystrophy, at early, mild and advanced stages. The inclusion also extends to subjects with, and without keratoconus. But this exclude patients with any other corneal disorders other than keratoconus, and/or history of ophthalmological surgeries that may affect endothelium cell status, e.g. cataract surgeries.

Overall Exclusion Criteria for all groups: Volunteers who

* Have occludable narrow angles (without a patent peripheral iridotomy)
* Monocular subjects
* Do not or cannot understand the instructions for the imaging

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Andy Yun, PhD — Masachusetts General Hospital
• Study coordinator: Fatima Clouser, MS
• Email: fclouser@mgh.harvard.edu
• Phone: 4077331679

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Measuring corneal properties to predict treatment outcomes

  This study is testing new ways to measure the shape and strength of the cornea to see if it can help predict how well treatments like LASIK will work for people with keratoconus or those needing eye surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03030755

• Corneal Crosslinking to Treat Progressive Keratoconus or Corneal Ectasia

  This study tests two different light durations used in corneal crosslinking to see which better helps people with keratoconus or corneal ectasia.

  Recruiting Phase 2/3 Price Vision Group · Indianapolis, Indiana · NCT07841470

• Brillouin hydration mapping to study cornea health

  Researchers test a Brillouin microscope to see if it can measure corneal water content in healthy people and those with eye conditions.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07780890

• EO2002 therapy for corneal edema due to endothelial dysfunction

  This trial tests whether a single intracameral injection of EO2002 cells can improve vision and reduce corneal thickness in adults with corneal edema from endothelial dysfunction.

  Recruiting Phase 2 Emmecell · Torrance, California and 9 other locations · NCT07729137

• Same-day bilateral corneal cross-linking for keratoconus

  This trial tests whether performing corneal cross-linking in both eyes on the same day is safe and feasible for people with keratoconus.

  Recruiting Phase 4 Glaukos Corporation · Westerville, Ohio · NCT07629557

• A Smart Aperture Lens to Help Keratoconus and Presbyopia

  This study tests the NOA lens, a custom scleral contact lens with a central aperture, to see if it improves vision for people with keratoconus and presbyopia.

  Recruiting at 2 sites Azalea Vision · Antwerp and 1 other locations · NCT07559188

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.