Optimizing scleral lens fittings using advanced imaging technology

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of Optical Coherence Tomography (OCT) in enhancing the fitting process for scleral contact lenses in patients with keratoconus and other corneal irregularities. Participants will undergo fittings using both clinically-selected and OCT-selected lenses, with the quality of each fit assessed through a fluorescein examination at the slit lamp. Key parameters such as apical clearance, limbal clearance, conjunctival compression, and lens edge lift will be measured to determine the optimal lens fit. The goal is to identify which fitting method provides better outcomes for patients requiring scleral lenses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eyes requiring fit for scleral lenses for KCN, post-PK, post-RK, post-LASIK ectasia, or various anterior surface disorders

Exclusion Criteria:

* Inability to maintain stable fixation for OCT imaging
* Inability to commit to required visits to complete the study
* Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit visual outcome

Where it's running

• Oregon Health & Science University, Casey Eye Institute
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: David Huang, MD, PhD — Oregon Health and Science University
• Study coordinator: Humberto Martinez, COT
• Email: martinhu@ohsu.edu
• Phone: 503-494-7712

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Corneal Crosslinking to Treat Progressive Keratoconus or Corneal Ectasia

  This study tests two different light durations used in corneal crosslinking to see which better helps people with keratoconus or corneal ectasia.

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• Same-day bilateral corneal cross-linking for keratoconus

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  Recruiting Phase 4 Glaukos Corporation · Westerville, Ohio · NCT07629557

• A Smart Aperture Lens to Help Keratoconus and Presbyopia

  This study tests the NOA lens, a custom scleral contact lens with a central aperture, to see if it improves vision for people with keratoconus and presbyopia.

  Recruiting at 2 sites Azalea Vision · Antwerp and 1 other locations · NCT07559188

• GLK-221 eye drops for keratoconus

  This trial will test whether twice-daily GLK-221 eye drops are safe and help adults aged 18–55 with keratoconus compared with a placebo.

  Recruiting Phase 2 Glaukos Corporation · Westerville, Ohio · NCT07400952

• Corneal wavefront-guided PRK plus epi-off CXL versus PTK plus epi-off CXL for keratoconus

  This trial tests whether adding corneal wavefront-guided PRK to epi-off corneal cross-linking gives better vision than PTK plus epi-off CXL in adults with keratoconus.

  Recruiting Instituto de Oftalmología Fundación Conde de Valenciana · Mexico City, Mexico City · NCT07372911

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.