Same-day bilateral corneal cross-linking for keratoconus

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 4 study evaluates the safety and practicality of applying riboflavin and UV-A light to both eyes during a single visit in patients with keratoconus. Participants will receive riboflavin ophthalmic solution and UV-A irradiation in both eyes on the same day and will be monitored through follow-up visits to assess adverse events and treatment feasibility. Eligible participants must have keratoconus in both eyes and agree to comply with study instructions. Exclusion criteria include known allergies to study meds, history of corneal disease, prior cross-linking in either eye, pregnancy, or recent participation in other investigational trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Provide written informed consent
* Willing and able to comply with study instructions and follow-up visits
* Diagnosis of keratoconus in each eye

Exclusion Criteria:

* Known allergy or sensitivity to study medications
* History of corneal disease
* Prior corneal cross-linking in either eye
* Pregnant, nursing, or planning pregnancy during the study period
* Participated in other investigational drug or device trial within 30 days of the study

Where it's running

• Glaukos Investigative Site
  Westerville, Ohio, United States Recruiting

Study contacts

• Study coordinator: Study Director
• Email: ClinicalResearch@glaukos.com
• Phone: 949-739-8749

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Corneal Crosslinking to Treat Progressive Keratoconus or Corneal Ectasia

  This study tests two different light durations used in corneal crosslinking to see which better helps people with keratoconus or corneal ectasia.

  Recruiting Phase 2/3 Price Vision Group · Indianapolis, Indiana · NCT07841470

• Brillouin hydration mapping to study cornea health

  Researchers test a Brillouin microscope to see if it can measure corneal water content in healthy people and those with eye conditions.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07780890

• A Smart Aperture Lens to Help Keratoconus and Presbyopia

  This study tests the NOA lens, a custom scleral contact lens with a central aperture, to see if it improves vision for people with keratoconus and presbyopia.

  Recruiting at 2 sites Azalea Vision · Antwerp and 1 other locations · NCT07559188

• GLK-221 eye drops for keratoconus

  This trial will test whether twice-daily GLK-221 eye drops are safe and help adults aged 18–55 with keratoconus compared with a placebo.

  Recruiting Phase 2 Glaukos Corporation · Westerville, Ohio · NCT07400952

• Corneal wavefront-guided PRK plus epi-off CXL versus PTK plus epi-off CXL for keratoconus

  This trial tests whether adding corneal wavefront-guided PRK to epi-off corneal cross-linking gives better vision than PTK plus epi-off CXL in adults with keratoconus.

  Recruiting Instituto de Oftalmología Fundación Conde de Valenciana · Mexico City, Mexico City · NCT07372911

• Epi-ON corneal crosslinking with UVA for people with Down syndrome and corneal ectasia

  This trial will try Epi-ON corneal crosslinking (riboflavin drops plus UVA light) to see if it can slow or stop corneal thinning and vision loss in people with Down syndrome who have keratoconus or similar ectatic corneal conditions.

  Recruiting at 12 sites Phase 3 Woolfson Eye Institute · Atlanta, Georgia and 11 other locations · NCT07135167

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.