Understanding keratoconus in children
Official title: The Collagen Factors of Rapid Progression of Keratoconus in Children: an Observational Cohort Study of the Physiological Parameter
Run by Zhongshan Ophthalmic Center, Sun Yat-sen University · NCT06722937 · Data updated 2026-11-12
This study looks at the signs and causes of keratoconus in children to see how it differs from adults and to better understand this eye condition that can affect vision.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 10 Years to 50 Years |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | April 14, 2023 |
| Main results expected | April 13, 2025 |
| Study ends | April 13, 2025 |
| Registry record updated | December 9, 2024 |
| Trial ID | NCT06722937 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children and young adults aged 10 to 50 years diagnosed with keratoconus who can comply with follow-up examinations.
✕Probably not a fit
Patients with a history of contact lens wear in the last four weeks or those with other significant eye diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the clinical features and mechanisms of keratoconus in children compared to adults. It focuses on understanding the characteristics of keratoconus in Chinese children and utilizes in vivo corneal laser confocal microscopy to observe corneal stromal cells at the cytological level. The study seeks to clarify the pathogenesis of this progressive corneal disease, which can lead to significant visual impairment if untreated.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of keratoconus in pediatric patients, potentially enhancing treatment outcomes.
How similar studies have gone: While there is ongoing research on keratoconus, this specific focus on pediatric patients and their unique progression patterns is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:
* ① Patients with keratoconus who visit the refractive clinic.
1. The height of the posterior corneal surface is greater than 16 microns under the Pentacam corneal topography.
2. ARTAve \< 424 microns, ARTMax \< 339 microns.
3. Clinical non-inflammatory or traumatic corneal thinning and corneal astigmatism.
* Aged between 10 and 50 years old, no gender restrictions.
* Agree to accept and complete follow-up examinations on time. ④ I and my guardian understand and agree to participate in this clinical trial and sign the informed consent form.
Exclusion Criteria:
* ① There is a history of contact lens wearing in the last four weeks.
* poor fixation and can not cooperate with the examination. ③ History of eye trauma and surgery (including corneal collagen cross-linking surgery).
* History of other related eye diseases: corneal disease, glaucoma, retinal choroid disease, etc..
⑤ severe eye diseases affecting imaging such as dry eye, conjunctivitis and pterygium.
⑥ Any systemic disease affecting eye morphology and refractive interstitium.
Where it's running
-
Zhongshan Ophthalmic Center,Sun Yat-Sen University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Dan Li, MD
- Email: canotoday@foxmail.com
- Phone: +86 188 1149 6522
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Corneal Crosslinking to Treat Progressive Keratoconus or Corneal Ectasia
This study tests two different light durations used in corneal crosslinking to see which better helps people with keratoconus or corneal ectasia.
-
Brillouin hydration mapping to study cornea health
Researchers test a Brillouin microscope to see if it can measure corneal water content in healthy people and those with eye conditions.
-
Same-day bilateral corneal cross-linking for keratoconus
This trial tests whether performing corneal cross-linking in both eyes on the same day is safe and feasible for people with keratoconus.
-
A Smart Aperture Lens to Help Keratoconus and Presbyopia
This study tests the NOA lens, a custom scleral contact lens with a central aperture, to see if it improves vision for people with keratoconus and presbyopia.
-
GLK-221 eye drops for keratoconus
This trial will test whether twice-daily GLK-221 eye drops are safe and help adults aged 18–55 with keratoconus compared with a placebo.
-
Corneal wavefront-guided PRK plus epi-off CXL versus PTK plus epi-off CXL for keratoconus
This trial tests whether adding corneal wavefront-guided PRK to epi-off corneal cross-linking gives better vision than PTK plus epi-off CXL in adults with keratoconus.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.