Condition

Down Syndrome (DS) clinical trials and research

• 7Clinical trials
• 5Countries

Newest Down Syndrome (DS) clinical trials

All recruiting trials (7)

• Levetiracetam to prevent seizures in adults with Down syndrome and Alzheimer's disease

  This trial will test whether the anti-seizure medicine levetiracetam can prevent tonic-clonic seizures and slow cognitive decline in adults over 40 who have Down syndrome and symptomatic Alzheimer's disease.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Granada, Andalusia and 4 other locations · NCT07234695

• Therapy plan for children with Down syndrome and acute myeloid leukemia in Russia

  This trial will test a standardized four-course chemotherapy program for children (0–18) with AML and Down syndrome in Russia to try to improve survival and reduce treatment side effects.

  Recruiting Phase 3 Federal Research Institute of Pediatric Hematology, Oncology and Immunology · Moscow · NCT07232134

• HEP therapy for motor and sensory development in infants with Down syndrome

  This study tests whether the HEP (Homeostasis‑Enrichment‑Plasticity) therapy helps motor and sensory development in babies aged 4–12 months with Down syndrome.

  Recruiting Medipol University · Istanbul, Beykoz · NCT07163780

• Epi-ON corneal crosslinking with UVA for people with Down syndrome and corneal ectasia

  This trial will try Epi-ON corneal crosslinking (riboflavin drops plus UVA light) to see if it can slow or stop corneal thinning and vision loss in people with Down syndrome who have keratoconus or similar ectatic corneal conditions.

  Recruiting at 12 sites Phase 3 Woolfson Eye Institute · Atlanta, Georgia and 11 other locations · NCT07135167

• Technology to promote healthy lifestyles in young people with intellectual disabilities

  This project will try a smartphone-based program with families and teachers to help children and young adults with intellectual disabilities move more and eat healthier.

  Recruiting University of Seville · Seville, Spain · NCT07101523

• Assessing Inspire therapy for adolescents with Down syndrome and severe sleep apnea

  This study is testing a new sleep therapy for teenagers with Down syndrome and severe sleep apnea to see if it helps them sleep better and improves their quality of life.

  Recruiting Inspire Medical Systems, Inc. · Phoenix, Arizona and 5 other locations · NCT06851338

• Effects of Suspension Therapy on Mobility and Balance in Children with Down Syndrome

  This study is testing if Suspension Therapy can help improve balance and mobility in young children with Down syndrome.

  Recruiting at 2 sites Riphah International University · Lahore, Punjab Province and 1 other locations · NCT06748248

Related topics

Quick answers

How many Down Syndrome (DS) clinical trials are recruiting right now?

7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (2 trials), Spain (2 trials), Turkey (Türkiye) (1 trial), Pakistan (1 trial), Russia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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