Condition

Pain, Acute clinical trials and research

• 26Clinical trials
• 12Countries

Newest Pain, Acute clinical trials

All recruiting trials (26)

• SAM aluminium splint for suspected wrist fractures

  This study will see if adding a SAM aluminium splint to usual care reduces pain for people with suspected wrist fractures who come to the emergency department.

  Recruiting Region Skane · Malmö · NCT07553000

• Combined acupressure to reduce post-thoracotomy pain and improve lung volume

  This trial will try combined acupressure on patients after thoracotomy to see if it reduces postoperative pain and helps restore lung volume.

  Recruiting Dogus Universitesi · Istanbul · NCT07411417

• Phase 1 testing of SBS-147 in healthy adults

  This study will test if SBS-147 is safe and how healthy adults' bodies handle single or repeated doses compared with a placebo.

  Recruiting Phase 1 Sparian Biosciences, Inc · Cypress, California · NCT07335913

• Butyrate and Taurine for Chronic Postoperative Pain in Adults after Cardiac Surgery

  This study tests whether taking taurine and butyrate daily can reduce long-lasting pain after cardiac surgery in adults.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT07144033

• Perioperative IV nimodipine for people undergoing open colectomy for bowel cancer

  This trial tests whether giving intravenous nimodipine around the time of open colectomy can reduce opioid use, lower pain, and speed early bowel recovery for people having surgery for bowel cancer.

  Recruiting University of Ioannina · Pátrai, Achaea · NCT07048522

• Paracetamol with ibuprofen versus paracetamol with metamizole for pain in children with acute pancreatitis

  We will test whether IV paracetamol combined with ibuprofen or IV paracetamol combined with metamizole reduces pain more effectively in children aged 3–18 with acute pancreatitis.

  Recruiting Phase 4 Medical University of Warsaw · Warsaw · NCT07024199

• Virtual reality to reduce discomfort during pacemaker and defibrillator implantation

  We will test whether using virtual reality during pacemaker or implantable defibrillator implantation helps lower pain and anxiety for adult patients compared with standard sedation alone.

  Recruiting University of Calabria · Cosenza · NCT07009951

• Buffered versus unbuffered lidocaine paracervical block to reduce pain and measure clinician empathy during IUD placement.

  This will see if buffered or unbuffered lidocaine injections, with or without topical numbing gel, reduce pain and change how much empathy patients feel from clinicians during IUD placement for people aged 18–50 getting an IUD.

  Recruiting University of California, San Diego · La Jolla, California · NCT06960317

• Using a kaleidoscope to reduce pain in children with burn injuries

  This study tests if using a kaleidoscope can help reduce pain for kids aged 7-12 with burn injuries during their dressing changes.

  Recruiting Vrinnevi Hospital · Empangeni, KwaZulu-Natal · NCT06933303

• Comparing two types of anesthesia for shoulder surgery recovery

  This study tests whether a single injection or a continuous drip of anesthesia helps adults recover better after shoulder surgery.

  Recruiting Phase 4 Pontificia Universidad Catolica de Chile · Santiago · NCT06754657

• Understanding pain relief variability after wisdom tooth extraction

  This study looks at how well ibuprofen helps people manage pain after getting their wisdom teeth removed and who might need extra pain relief to avoid using opioids.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06539741

• Understanding chronic pain after heart surgery

  This study looks at what causes long-lasting pain in people aged 18-80 after heart surgery to help improve pain management for these patients.

  Recruiting Ankara Etlik City Hospital · Ankara, Ankara and 1 other locations · NCT06534372

• Exploring how muscle pain affects walking mechanics

  This study tests how causing muscle pain affects the way healthy people walk and use their muscles.

  Recruiting Aalborg University · Aalborg, North Denmark · NCT06411197

• Using acu-TENS to reduce pain during ultrasound-guided manual vacuum aspiration

  This study is testing if a new pain relief method called acu-TENS can help women feel less pain during a procedure for early pregnancy loss.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06411054

• Using TENS for pain relief during outpatient urethral bulking in women with stress urinary incontinence.

  This study is testing if using a TENS machine can help reduce pain for women undergoing a specific procedure for stress urinary incontinence.

  Recruiting University of Rochester · Rochester, New York · NCT06369922

• Using nebulized ketamine and fentanyl to treat acute pain in the emergency department

  This study tests whether using a mist of ketamine or fentanyl can help adults in the emergency room with severe pain feel better when they can't take medicine through an IV.

  Recruiting Phase 4 Maimonides Medical Center · Brooklyn, New York · NCT06364540

• Vitamin C to reduce pain after an emergency department visit

  This trial tries to see if a single 900 mg dose of vitamin C, followed by 900 mg twice daily for three days, can reduce pain in adults who come to the emergency department with a new musculoskeletal injury.

  Recruiting Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Ottawa, Ontario and 3 other locations · NCT06306183

• Using Stellate Ganglion Block to Prevent Depression After Mastectomy

  This study tests whether a special nerve block can help prevent depression and pain in women who are having surgery for breast cancer.

  Recruiting Mansoura University · Al Mansurah · NCT06263907

• Using TENS units to reduce pain during IUD insertion

  This study is testing if using TENS units can help reduce pain for women aged 12 to 50 during IUD insertion.

  Recruiting Tufts Medical Center · Boston, Massachusetts · NCT06240260

• Improving surgical outcomes for Latinx children

  This study is testing a mobile health program to help Latinx children aged 2-7 feel less anxious and manage pain better before and after their outpatient surgeries.

  Recruiting University of California, Irvine · Orange, California · NCT06020677

• Freezing Nerves to Relieve Pain from Rib Fractures

  This study is testing if freezing the nerves can help people with rib fractures feel less pain compared to a fake treatment.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT05865327

• Comparing pain perception with fast and slow tenaculum application techniques

  This study is testing whether placing a tenaculum slowly on the cervix causes less pain than doing it quickly for women undergoing this procedure.

  Recruiting Women and Infants Hospital of Rhode Island · Providence, Rhode Island · NCT05458037

• Using Valacyclovir to Manage Pain from Acute Apical Abscesses

  This study tests if adding valacyclovir to antibiotics can help reduce pain for people with acute apical abscesses.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT05266040

• Effects of cognitive-behavioral programs on children's pain and anxiety during blood collection

  This study tests if using video games or a kaleidoscope can help reduce pain and anxiety for kids aged 8-10 during blood draws, while also looking at how their parents feel about the experience.

  Recruiting Karamanoğlu Mehmetbey University · Karaman and 1 other locations · NCT05263297

• Evaluating pain pathways and nerve regeneration in keratoconus patients after corneal crosslinking

  This study is testing how corneal crosslinking affects pain and nerve healing in people with keratoconus to see how their pain changes over time.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04439552

• Using nitrous oxide canisters for pain relief during burn dressing changes

  This study is testing whether using nitrous oxide canisters can help adults with burns feel less pain during dressing changes compared to a placebo.

  Recruiting Early Phase 1 University of Manitoba · Winnipeg, Manitoba · NCT03695887

Related topics

Quick answers

How many Pain, Acute clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (10 trials), Canada (3 trials), Turkey (Türkiye) (3 trials), Hong Kong (2 trials), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2: 1, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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