Investigating how gut bacteria affect irritable bowel syndrome after infections
Official title: Microbiota based mechanisms of post-infection irritable bowel syndrome
Funded at Mayo Clinic Rochester · NIH-10896327 · Data updated 2026-11-12
This study is looking at how certain gut bacteria might play a role in causing irritable bowel syndrome (IBS) after an intestinal infection, and it aims to find ways to improve gut health and ease IBS symptoms for people who have experienced this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 21, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $335,808 |
| NIH project number | 5R01DK127998-04 |
| Project ID | NIH-10896327 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who have developed irritable bowel syndrome following an intestinal infection.
✕Less likely to help
Patients who do not have a history of intestinal infections or do not suffer from IBS may not benefit from this research.
What this research studies
This research explores the connection between gut bacteria and the development of irritable bowel syndrome (IBS) following intestinal infections. It focuses on understanding how certain bacteria, particularly from the Alistipes genus, influence the activity of proteases in the gut, which can lead to symptoms of IBS. By studying fecal samples and using germ-free mice models, the researchers aim to identify specific microbial interactions that could help restore gut health and alleviate IBS symptoms. Patients with post-infection IBS may provide valuable insights into how these bacteria function and how they can be targeted for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore gut health and reduce IBS symptoms for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in gastrointestinal disorders, suggesting that this approach could yield significant insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Grover, Madhusudan — Mayo Clinic Rochester
- Study coordinator: Grover, Madhusudan
Related research
Other NIH-funded projects on the same topics.
-
Proteolytic Activity-Guided Fecal Microbiota Transplant for PI-IBS
A pilot study will test a targeted fecal microbiota transplant to help adults with post-infection irritable bowel syndrome feel better and have fewer GI symptoms.
-
A new way to use gut bacteria transplants for Irritable Bowel Syndrome
This research explores if a special type of fecal microbiota transplant, guided by specific gut enzyme activity, can safely and effectively improve symptoms for adults with Irritable Bowel Syndrome that developed after an infection.
-
How missing gut bacteria may drive post-infection irritable bowel syndrome
This project aims to restore missing gut bacteria in adults with post-infection IBS to reduce harmful protein‑breaking enzymes that may cause gut damage and symptoms.
-
Exploring gut bacteria and metabolites to find new types of Irritable Bowel Syndrome
This study is looking at how the bacteria in your gut and their byproducts can help us understand the different types of Irritable Bowel Syndrome (IBS) and find better ways to treat it, so if you have IBS, your participation could help improve your care!
-
Using targeted fecal microbiota transplantation to treat irritable bowel syndrome
This study is looking at whether a special treatment called fecal microbiota transplantation (FMT) can help people with irritable bowel syndrome (IBS) who started having symptoms after an intestinal infection, by using healthy gut bacteria from carefully chosen donors to improve their gut health.
-
Identifying new subtypes of irritable bowel syndrome using gut bacteria and metabolites.
This study is looking at how the bacteria in your gut and their byproducts can help us understand the different types of irritable bowel syndrome (IBS) and figure out which treatments might work best for you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.