Investigating how gut bacteria affect irritable bowel syndrome after infections
Microbiota based mechanisms of post-infection irritable bowel syndrome
This study is looking at how certain gut bacteria might play a role in causing irritable bowel syndrome (IBS) after an intestinal infection, and it aims to find ways to improve gut health and ease IBS symptoms for people who have experienced this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10896327 on NIH RePORTER |
What this research studies
This research explores the connection between gut bacteria and the development of irritable bowel syndrome (IBS) following intestinal infections. It focuses on understanding how certain bacteria, particularly from the Alistipes genus, influence the activity of proteases in the gut, which can lead to symptoms of IBS. By studying fecal samples and using germ-free mice models, the researchers aim to identify specific microbial interactions that could help restore gut health and alleviate IBS symptoms. Patients with post-infection IBS may provide valuable insights into how these bacteria function and how they can be targeted for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who have developed irritable bowel syndrome following an intestinal infection.
Not a fit: Patients who do not have a history of intestinal infections or do not suffer from IBS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore gut health and reduce IBS symptoms for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in gastrointestinal disorders, suggesting that this approach could yield significant insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Grover, Madhusudan — Mayo Clinic Rochester
- Study coordinator: Grover, Madhusudan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.