Identifying new subtypes of irritable bowel syndrome using gut bacteria and metabolites.

Who could benefit from this research

What this research studies

This research investigates how the interactions between gut bacteria and metabolites can reveal different subtypes of irritable bowel syndrome (IBS). By analyzing fecal samples and using advanced statistical methods, the study aims to identify which patients are more likely to respond to specific treatments. The approach includes training in laboratory techniques and predictive analytics to enhance understanding of IBS. This could lead to more personalized treatment options for patients suffering from IBS.

Why it matters

Where this research is happening

• University of Michigan at Ann Arbor
  Ann Arbor, United States Active

Researchers

• Principal investigator: Lee, Allen a — University of Michigan at Ann Arbor
• Study coordinator: Lee, Allen a

Related research

Other NIH-funded projects on the same topics.

• Exploring gut bacteria and metabolites to find new types of Irritable Bowel Syndrome

  This study is looking at how the bacteria in your gut and their byproducts can help us understand the different types of Irritable Bowel Syndrome (IBS) and find better ways to treat it, so if you have IBS, your participation could help improve your care!

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10848525

• Proteolytic Activity-Guided Fecal Microbiota Transplant for PI-IBS

  A pilot study will test a targeted fecal microbiota transplant to help adults with post-infection irritable bowel syndrome feel better and have fewer GI symptoms.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11377587

• Gut bacteria, inflammation, and metabolism in heat-related sickness among farmworkers

  This project looks at whether gut bacteria, inflammation, and certain blood chemicals are linked to heat-related sickness in people who work in extreme heat.

  NIH research Emory University · Atlanta, United States · NIH-11250120

• A new way to use gut bacteria transplants for Irritable Bowel Syndrome

  This research explores if a special type of fecal microbiota transplant, guided by specific gut enzyme activity, can safely and effectively improve symptoms for adults with Irritable Bowel Syndrome that developed after an infection.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11176806

• How missing gut bacteria may drive post-infection irritable bowel syndrome

  This project aims to restore missing gut bacteria in adults with post-infection IBS to reduce harmful protein‑breaking enzymes that may cause gut damage and symptoms.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11144404

• Exploring how gut bacteria and inflammation affect heat-related illness

  This study is looking at how the bacteria in our gut might affect inflammation and heat-related illnesses in farm workers who work in extreme heat, to help find ways to prevent or treat these conditions.

  NIH research Emory University · Atlanta, United States · NIH-11020714

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.