Psyllium with meals for fructan-triggered pain in children with IBS
Official title: ASSESSING PSYLLIUM GIVEN WITH MEALS FOR FRUCTAN SENSITIVITY IN CHILDREN WITH IRRITABLE BOWEL SYNDROME
Funded at Duke University · NIH-11374563 · Data updated 2026-11-12
A small study in children with IBS will test whether adding psyllium with meals helps reduce tummy pain caused by fructan in certain foods.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 5, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $279,099 |
| NIH project number | 5R01DK135668-03 |
| Project ID | NIH-11374563 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are children with IBS who show worsening symptoms after fructan-containing foods and who can tolerate fiber supplementation under medical supervision.
✕Less likely to help
Some children may not experience pain relief from psyllium or may have intolerance to fiber or adverse effects.
What this research studies
This study focuses on children with irritable bowel syndrome who are fructan-sensitive. Researchers will give psyllium fiber with meals and monitor its effect on abdominal pain and dietary tolerance. The approach builds on findings that gut microbes and fructan fermentation influence symptoms and that psyllium may slow fermentation and lessen pain. The goal is to see if a simple fiber addition can offer a practical treatment option beyond dietary restrictions.
Why it matters
Potential benefit: If successful, children with IBS and fructan sensitivity may experience less abdominal pain and improved comfort with everyday meals.
How similar studies have gone: Previous work in children with IBS suggests dietary and microbiome-based approaches can influence symptoms, with promising signals for fiber-related strategies.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Chumpitazi, Bruno Pedro — Duke University
- Study coordinator: Chumpitazi, Bruno Pedro
Related research
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Abdominal Myofascial Release for IBS-C in patients of all ages
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.