Using a device at home to stimulate a nerve in the ear to help manage pain in young adults with IBS
Official title: Home-Based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Pain and Symptom Management among Young Adults with Irritable Bowel Syndrome (IBS)
Funded at Yale University · NIH-11122461 · Data updated 2026-11-12
This study is looking at whether a gentle ear stimulation technique done at home can help young adults with irritable bowel syndrome (IBS) feel better by easing their pain and symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $762,489 |
| NIH project number | 1R34AT012917-01A1 |
| Project ID | NIH-11122461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young adults aged 18-29 who have been diagnosed with irritable bowel syndrome.
✕Less likely to help
Patients outside the age range of 18-29 or those not diagnosed with irritable bowel syndrome may not benefit from this research.
What this research studies
This research investigates the use of home-based transcutaneous auricular vagus nerve stimulation (taVNS) as a non-invasive method to help manage pain and symptoms in young adults suffering from irritable bowel syndrome (IBS). The approach focuses on stimulating a specific nerve in the ear to potentially improve the brain-gut interaction and alleviate distressing symptoms associated with IBS. Participants will be involved in a randomized trial comparing the effects of active taVNS versus a sham treatment, assessing factors such as feasibility, safety, and adherence to the intervention. This study aims to explore a practical and accessible pain management strategy for young adults aged 18-29 with IBS.
Why it matters
Potential benefit: If successful, this research could provide a new, effective, and non-pharmacological treatment option for managing IBS-related pain and symptoms in young adults.
How similar studies have gone: Previous research has shown promise for non-pharmacological interventions like taVNS in various populations, suggesting potential success for this approach in young adults with IBS.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Cong, Xiaomei Sophia — Yale University
- Study coordinator: Cong, Xiaomei Sophia
Related research
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IBS after COVID-19: how SARS-CoV-2 infection may lead to irritable bowel syndrome
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Identifying biomarkers for diarrhea-predominant irritable bowel syndrome using stool samples
This study is looking to make it easier to diagnose diarrhea-predominant irritable bowel syndrome (IBS-D) by checking stool samples for certain markers, so if you have IBS-D, researchers want to find a simple and non-invasive way to help identify your condition better.
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Proteolytic Activity-Guided Fecal Microbiota Transplant for PI-IBS
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Psyllium with meals for fructan-triggered pain in children with IBS
A small study in children with IBS will test whether adding psyllium with meals helps reduce tummy pain caused by fructan in certain foods.
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A pilot study will test whether a home-based VR cognitive behavioral therapy program helps people with irritable bowel syndrome feel better and manage symptoms compared with a sham VR experience.
-
Understanding how alcohol and the gut’s serotonin system affect IBS
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.