Condition

Chronic Liver Disease clinical trials and research

• 15Clinical trials
• 7NIH research projects
• 13Countries

Newest Chronic Liver Disease clinical trials

All recruiting trials (15)

• Copper supplementation for people with cirrhosis

  This trial will try giving copper supplements to adults with cirrhosis who have low copper levels or signs of copper deficiency to see if liver-related health improves.

  Recruiting University of Washington · Seattle, Washington · NCT07471542

• Understanding how chronic liver disease patients with organ failure fare after non‑emergency hospital stays

  This study follows adults with chronic liver disease who are admitted to the hospital non-electively to see how their condition develops over six months when liver and/or other organs fail.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT07270809

• Understanding social and health needs of people with chronic liver disease in outpatient care

  This project will see how common social needs are and whether adults with chronic liver disease want their outpatient providers to help with them.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07191886

• Using rifaximin to improve liver transplant outcomes

  This study is testing if taking the antibiotic rifaximin before and after liver transplant surgery can help prevent early problems with the new liver in adults.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT06743464

• Endoscopic ultrasound shear wave elastography for measuring liver fibrosis

  This study will test whether endoscopic ultrasound shear wave elastography and attenuation imaging can estimate liver fibrosis compared with biopsy and FibroScan in adults with suspected MASLD or MASH.

  Recruiting at 3 sites Olympus Corporation of the Americas · Newport Beach, California and 2 other locations · NCT06592820

• Comparing intravenous and under-skin LAENNEC for alcoholic and non-alcoholic fatty liver disease

  This will test whether 10 ml intravenous LAENNEC given twice weekly for six weeks works better and is as safe as 4 ml subcutaneous LAENNEC in adults 19–70 with alcoholic or non‑alcoholic fatty liver disease.

  Recruiting Phase 3 Green Cross Wellbeing · Yongin-si · NCT06493799

• Gathering data on hepatomiR for liver disease outcomes

  This study is trying to see how a new test for liver disease can help doctors understand and predict serious problems in patients with chronic liver issues.

  Recruiting Karl Landsteiner University of Health Sciences · Sankt Pölten, Lower Austria · NCT06432582

• Hepatoscope screening and referral for people at risk of liver fibrosis

  This test tries a portable Hepatoscope ultrasound in people flagged as at-risk by a FIB-4 blood score to see if it can detect liver fibrosis and prompt referral to hepatology.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06387745

• Using albumin modifications to identify early signs of chronic liver disease

  This study is testing if changes in a protein called albumin in the blood can help spot early signs of chronic liver disease in people who may already have liver damage.

  Recruiting at 5 sites University Hospital, Limoges · Angers and 6 other locations · NCT06318949

• Understanding Hepatitis D and its impact on patients

  This study is trying to understand how Hepatitis D affects patients by looking at their backgrounds and health to help create better treatment plans.

  Recruiting at 3 sites Hannover Medical School · Hanover and 3 other locations · NCT06160635

• Evaluating patients with chronic liver diseases linked to fat accumulation in the liver

  This study is trying to understand how fat buildup in the liver affects people with chronic liver diseases to help find better ways to diagnose and treat these conditions.

  Recruiting University of Copenhagen · Hvidovre · NCT05335603

• Fast-MRI to improve liver cancer surveillance in high-risk patients

  This trial will test whether adding a fast liver MRI to the routine six-month ultrasound finds early liver cancers sooner in adults with cirrhosis who have an annual HCC risk above 3%.

  Recruiting Assistance Publique - Hôpitaux de Paris · Bondy · NCT05095714

• Comparing 2-dose and 3-dose hepatitis B vaccine regimens in cirrhosis patients

  This study is testing whether giving two or three doses of the hepatitis B vaccine works better for people with cirrhosis who need protection against the virus.

  Recruiting Phase 4 Mercy Medical Center · Baltimore, Maryland · NCT04588077

• Evaluating non-invasive methods for diagnosing chronic liver disease

  This study is trying to see if non-invasive tests can help predict how well people with chronic liver disease will do over time.

  Recruiting Association HGE CHU Bordeaux Sud · Pessac · NCT02060565

• Community-based liver health assessment using noninvasive biomarkers

  This study is trying to see how well non-invasive tests can help identify liver health issues in people at risk, like those with diabetes or obesity, by gathering information from around 2,000 participants over four years.

  Recruiting University of Nottingham · Nottingham, Notts · NCT02037867

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How bone marrow cells react to long‑term liver disease and how this affects inflammation

  This grant looks at how chronic liver disease changes bone marrow and drives body-wide inflammation, with the goal of finding safer ways to calm that inflammation.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11450458

• Fat and iron–corrected MRI to evaluate chronic liver disease

  A new MRI method aims to measure fat, iron, and tissue changes in adults with chronic liver disease to help track MASLD/MASH progression.

  NIH research New York University School of Medicine · New York, United States · NIH-11406093

• How liver scar‑forming cells remember past injury

  The team is looking at how scar‑forming cells in the liver change after repeated injury to help people with chronic liver disease.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11290373

• Understanding Genetic Changes in Liver Cells and Chronic Liver Disease

  This project explores how small genetic changes that naturally happen in our liver cells might influence chronic liver disease and its progression.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11184312

• Understanding liver macrophages to predict fibrosis risk in chronic liver disease

  This study is looking at how certain immune cells in the liver can help doctors understand the risk of liver damage in people with chronic liver diseases, like fatty liver disease or alcohol-related liver issues, so they can create personalized treatments to prevent serious problems.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11083599

• Understanding how liver cells remember past injuries and contribute to liver fibrosis

  This study is looking at how certain liver cells remember past injuries and cause scarring in the liver, which can help us find new ways to treat chronic liver disease.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11042764

• Understanding how genetic changes affect chronic liver disease

  This study is looking at how changes in your genes might affect chronic liver disease and its progression to cirrhosis, with the goal of finding new ways to help manage liver health.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10937001

Related topics

Quick answers

How many Chronic Liver Disease clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (4 trials), France (3 trials), India (2 trials), Guadeloupe (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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