Condition

Hepatitis C clinical trials and research

• 23Clinical trials
• 40NIH research projects
• 7Countries

Newest Hepatitis C clinical trials

All recruiting trials (23)

• Glecaprevir/pibrentasvir started during pregnancy for women with hepatitis C, with or without HIV

  This trial will test whether taking glecaprevir/pibrentasvir during pregnancy is safe and how the drug is processed in pregnant women who have hepatitis C, including those who also have HIV, and will follow their infants for 10 weeks after birth.

  Recruiting at 8 sites Phase 1/2 National Institute of Allergy and Infectious Diseases (NIAID) · Los Angeles, California and 9 other locations · NCT07040319

• Evaluating hepatitis C treatment during pregnancy

  This study tests how well a new hepatitis C treatment works for pregnant adults with a history of drug use and looks at their experience during the treatment.

  Recruiting at 2 sites Washington University School of Medicine · St Louis, Missouri and 1 other locations · NCT06367465

• Decentralized treatment for hepatitis C in Brazil

  This study is testing a new way to treat hepatitis C in Brazil using a medication called Epclusa to see if it helps more people get the care they need compared to traditional methods.

  Recruiting at 2 sites Phase 4 Oswaldo Cruz Foundation · Rio de Janeiro, Rio de Janeiro and 1 other locations · NCT06306300

• Helping young people who inject drugs start treatment for Hepatitis C

  This study tests a new support program to help young adults who inject drugs start treatment for Hepatitis C and see if it works better than regular care.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06179498

• Simplified hepatitis C testing with same-day treatment for people who inject drugs in Armenia, Georgia and Tanzania

  This project will test whether a simplified pathway that starts hepatitis C treatment the same day after a quick antibody test helps people who inject drugs in Armenia, Georgia, and Tanzania get treated and cured faster than the usual antibody-plus-RNA pathway.

  Recruiting Early Phase 1 Médecins du Monde · Yerevan · NCT06159504

• Point-of-care testing program for Hepatitis C screening

  This study is testing if quick Hepatitis C tests done during a single visit can help more at-risk adults get diagnosed and start treatment faster.

  Recruiting at 6 sites Kirby Institute · Canberra, Australian Capital Territory and 12 other locations · NCT05713136

• Screening for hepatitis B, hepatitis C and HIV using a dried blood spot

  This project will try a simple dried blood spot test to check people who use drugs for hepatitis B, hepatitis C and HIV.

  Recruiting at 11 sites University Hospital, Rouen · Avranches and 10 other locations · NCT05390424

• Registry for treating hepatitis C in pregnant women

  This study is collecting information on pregnant women treated with new hepatitis C medications to see if they are safe for both mothers and their babies.

  Recruiting The Task Force for Global Health · Atlanta, Georgia · NCT05368974

• Screening for Hepatitis B, C, and HIV among Drug Users

  This study is testing if having regular screening days for hepatitis B, C, and HIV can help drug users get better access to testing and treatment in a supportive environment.

  Recruiting University Hospital, Limoges · Limoges, Haute Vienne · NCT05361603

• Evaluating point-of-care testing for Hepatitis C in Australia

  This study is testing if quick finger-stick tests for Hepatitis C can help people in high-risk areas in Australia get diagnosed and treated more easily.

  Recruiting at 11 sites Kirby Institute · Sydney, New South Wales and 15 other locations · NCT05248555

• Collecting blood samples from healthy individuals and patients with cancer or benign diseases

  This study is collecting blood samples from healthy people and patients with cancer or non-cancer conditions to see if certain DNA markers can help detect cancer more accurately.

  Recruiting at 6 sites Helio Genomics · Redondo Beach, California and 6 other locations · NCT05181826

• National program for point-of-care testing of Hepatitis C in Australia

  This study is testing if quick finger-stick tests for Hepatitis C can help more people at risk get diagnosed and treated in places like drug clinics and prisons.

  Recruiting at 52 sites Kirby Institute · Canberra, Australian Capital Territory and 68 other locations · NCT05042544

• How chronic liver diseases connect with other long-term illnesses

  We will look back at hospital records to see if chronic liver diseases are linked with other systemic illnesses in adults who visited Tzu Chi gastroenterology clinics.

  Recruiting Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation · New Taipei City · NCT04525833

• Using hearts from donors with active hepatitis C (HCV NAT+) for transplantation

  This tests whether receiving a heart from a donor with active hepatitis C (HCV NAT+) is safe and leads to acceptable outcomes for people having a heart transplant.

  Recruiting Baylor Research Institute · Dallas, Texas · NCT04493385

• Using an app to educate patients about Hepatitis C in the emergency department

  This study is testing an app that helps patients in the emergency department learn more about Hepatitis C to improve their understanding and get them started on treatment.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT04162938

• Short-term treatment for early liver disease caused by Hepatitis C

  This study is testing a 4-week treatment plan for people with early liver disease caused by Hepatitis C to see if it can safely get rid of the virus.

  Recruiting at 3 sites Phase 4 Kirby Institute · Darlinghurst, New South Wales and 2 other locations · NCT03855917

• Improving hepatitis C treatment in drug treatment clinics

  This study is testing if providing hepatitis C testing and treatment directly at drug treatment clinics can help people who use drugs get better care for their hepatitis C.

  Recruiting at 25 sites Kirby Institute · Canberra, Australian Capital Territory and 31 other locations · NCT03685045

• Implementing HIV testing in opioid treatment programs

  This study is testing if coaching programs can help people in opioid treatment programs get more HIV and Hepatitis C tests and connect to care.

  Recruiting Columbia University · New York, New York · NCT03135886

• Biorepository for liver disease samples

  This study is collecting samples from patients with liver diseases to help researchers find better treatments and improve care for these conditions.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT03025074

• Nationwide treatment program for Hepatitis C in Iceland

  This study is testing a new treatment program for Hepatitis C in Iceland to see if it can effectively help everyone with the virus and reduce new infections over the next 15 years.

  Recruiting Landspitali University Hospital · Reykjavik · NCT02647879

• Monitoring liver transplant recipients for early detection of complications

  This study is testing if checking blood, urine, and tissue samples from liver transplant patients can help spot early signs of kidney problems, organ rejection, and Hepatitis C to improve their treatment and health outcomes.

  Recruiting Northwestern University · Chicago, Illinois · NCT01644903

• Studying how genetic testing can improve medication use in patients

  This study is trying to see if using genetic testing can help doctors choose the right medications for patients with heart diseases, inflammatory bowel diseases, and autoimmune diseases to improve their treatment outcomes.

  Recruiting University of Chicago · Chicago, Illinois · NCT01280825

• Evaluation of patients with liver disease

  This study is trying to learn more about liver diseases by checking in on patients with conditions like hepatitis B, C, and D through regular tests and follow-ups.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001971

NIH-funded research (40)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Rational hepatitis C vaccine design guided by natural clearance patterns

  A Johns Hopkins team is studying how some people naturally clear hepatitis C to guide a vaccine that could prevent infection.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11451365

• Real-world patient and clinician preferences to improve prenatal care for women with OUD and HCV

  Researchers are exploring how pregnant women with opioid use disorder and hepatitis C, along with their clinicians, would like to receive care to improve outcomes for moms and babies.

  NIH research Boston Medical Center · Boston, United States · NIH-11432865

• Co-infection patterns of HIV, hepatitis C, and sexually transmitted infections among rural people who inject drugs during an HIV outbreak

  A small, patient-focused study will look at how HIV, hepatitis C, and other sexually transmitted infections occur together in rural people who inject drugs during an HIV outbreak, and what factors relate to these co-infections.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11408843

• Low-threshold hepatitis C treatment in jail to help people released back to the community

  A patient-friendly plan to test a simple, quick hepatitis C treatment in jail for people who use drugs, with care that continues after release.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11394546

• Precise, rapid HCV detection from blood at the point of care

  Aiming to provide a fast, easy blood test to detect hepatitis C right where care is delivered.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11389431

• Hepatitis C screening tool used in the Emergency Department

  A new ED screening tool helps identify people at risk for hepatitis C so they can get diagnosed and treated sooner.

  NIH research University of Florida · Gainesville, United States · NIH-11382461

• Kentucky outreach kiosks to prevent overdoses, hepatitis C, and HIV in rural Appalachia

  This project is trying out public health kiosks to offer anonymous syringe services, naloxone, testing, and care referrals to people who inject drugs in rural Appalachian Kentucky.

  NIH research University of Kentucky · Lexington, United States · NIH-11373832

• Hepatitis C elimination for people who inject drugs through better care and HIV connection

  Aims to model how to best improve hepatitis C care among people who inject drugs, especially when they also have HIV, to reduce infections and healthcare costs.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11362730

• Point-of-care hepatitis C test that detects the virus quickly in outpatient clinics

  A new rapid, same-visit test aims to find hepatitis C at the point of care in outpatient clinics so people can start treatment faster.

  NIH research University of Washington · Seattle, United States · NIH-11357656

• Investigating the safety and effectiveness of a hepatitis C treatment during pregnancy

  This study is looking at how safe and effective the medications Glecaprevir and Pibrentasvir are for pregnant people with hepatitis C, including those with HIV, and will track their health and their baby's health for three months after birth to make sure everyone stays safe and healthy.

  NIH research Westat, INC. · Rockville, United States · NIH-11344777

• Improving Hepatitis C Care for People Who Inject Drugs

  This project uses computer models to understand the best ways to eliminate hepatitis C among people who inject drugs, especially those also living with HIV.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11333521

• Preventing hepatitis C after receiving a kidney from an HCV-positive donor

  This compares two ways of giving hepatitis C antivirals to people getting a kidney from an HCV-positive donor to find which best prevents infection and complications.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11319833

• Liver CD4+ T cells that help clear hepatitis C

  This project looks for patterns in liver CD4+ T cells that help people clear hepatitis C and could guide better vaccines.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11306593

• Closing Gaps in Hepatitis C Care with Real‑World Data

  Researchers will use electronic health records and registries from two large urban health systems to understand how national policies affect hepatitis C testing, treatment, and follow-up in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11279938

• How the immune system remembers hepatitis C

  Researchers will follow people cured of chronic hepatitis C to learn how their antibody-making B cells recover and respond to future HCV exposure.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11247527

• Rapid point-of-care Hepatitis C test with a long-lasting glowing signal

  This project is creating a fast, low-cost bedside test to detect active Hepatitis C infections for people in underserved and remote communities.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11237148

• Low‑barrier hepatitis C care for people in jail

  This project offers simple, take‑home hepatitis C medicine plus community navigation to people who inject drugs who are jailed, including those living with HIV.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11192887

• How a small RNA segment controls hepatitis C virus behavior

  This project looks at how a tiny, non‑coding piece of the hepatitis C virus's genetic material helps the virus replicate and form particles, which matters to people with hepatitis C.

  NIH research University of Kansas Lawrence · Lawrence, United States · NIH-11172628

• Emergency-department tool to detect Hepatitis C

  An AI-guided screening tool will be used in emergency departments to help find adults with undiagnosed Hepatitis C, especially people who inject drugs or have HIV.

  NIH research University of Florida · Gainesville, United States · NIH-11143909

• A new test for diagnosing Hepatitis C in outpatient clinics

  This study is working on a quick and easy test for Hepatitis C that you can take without needing a blood draw or fancy lab equipment, so more people can get tested and treated, especially those who might not even know they have the virus.

  NIH research University of Washington · Seattle, United States · NIH-11131266

• Understanding dry mouth caused by hepatitis C virus

  This study is looking at how chronic hepatitis C can cause dry mouth, and it aims to understand the changes in saliva and salivary glands in people with this condition, so we can find better ways to help those who experience this uncomfortable symptom.

  NIH research Healthpartners Institute · Bloomington, UNITED STATES · NIH-11122313

• Health Kiosks to Reduce Drug-Related Risks in Rural Appalachia

  This project is exploring if health kiosks can help people in rural Appalachian Kentucky who use injection drugs reduce their risks of overdose, hepatitis C, and HIV.

  NIH research University of Kentucky · Lexington, United States · NIH-11118797

• Understanding how the immune system fights hepatitis C virus

  This study is looking at how a type of immune cell called CD4+ T cells helps the body fight the hepatitis C virus, with the goal of finding ways to create a vaccine that can protect people from this virus.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11108516

• Using perinatal care to help reduce opioid overdoses and hepatitis C infections

  This study is looking at how caring for women during pregnancy can help them get better treatment for opioid use disorder and hepatitis C, making it easier for them to stay engaged in their health care.

  NIH research Boston Medical Center · Boston, United States · NIH-11078478

• How the immune system and vaccines can help people clear hepatitis C

  This work looks at how people’s immune systems and candidate vaccines help some people clear hepatitis C, aiming to guide better vaccines for people at risk of infection.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11076719

• Developing a vaccine to protect against hepatitis C virus

  This study is working on a vaccine to help people who have been exposed to the hepatitis C virus by boosting their immune system to fight off the virus, similar to how some people naturally recover from it.

  NIH research Stanford University · Stanford, United States · NIH-11074564

• Transplanting kidneys from Hepatitis C–positive donors into Hepatitis C–negative recipients

  This project gives kidneys from Hepatitis C–positive donors to people without Hepatitis C and uses antiviral drugs after transplant to prevent lasting infection.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11057580

• Comparing antiviral treatments for kidney transplants from hepatitis C-infected donors to uninfected recipients

  This study is looking at the best way to use new medicines to prevent hepatitis C in kidney transplant patients when the donor has the virus, comparing whether it's better to give the medicine before or after the transplant, and it's for people who are getting a kidney transplant from a donor with hepatitis C.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11043309

• Quick detection of Hepatitis C virus using advanced technology

  This study is working on a quick and easy test to help find Hepatitis C infections, especially for people in underserved communities like American Indians and Alaska Natives, so they can get the treatment they need sooner.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11025330

• Providing hepatitis C treatment in jails

  This study is looking at a new way to help people in jail who have hepatitis C, especially those who also have HIV, by giving them easy access to treatment and support so they can manage their health while they're incarcerated and after they get out.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11007380

• Investigating how the immune system responds to hepatitis C virus after treatment

  This study is looking at how the immune system remembers the hepatitis C virus after treatment, to help understand why some people might get reinfected and to improve vaccines for those at higher risk, and we’d love for patients to help by sharing samples for this important research.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11005205

• Understanding how Hepatitis C virus RNA interacts with itself

  This study is looking at how certain parts of the Hepatitis C virus communicate with each other, which could help us find better ways to treat the virus and improve outcomes for people living with Hepatitis C.

  NIH research University of Kansas Lawrence · Lawrence, United States · NIH-10937178

• Developing a tool to screen for Hepatitis C in emergency departments

  This study is working on a new way to help emergency departments quickly find people who might have Hepatitis C, especially those at higher risk because of opioid use, so they can get diagnosed and treated sooner.

  NIH research University of Florida · Gainesville, United States · NIH-10925373

• How hepatitis C and HIV together affect aging and liver cancer risk

  This study is looking at how having both hepatitis C and HIV affects aging and the risk of liver cancer in people from Latin America, and it hopes to find ways to help detect and prevent cancer in those living with these infections.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10872804

• Using perinatal care to reduce opioid overdoses and hepatitis C infections

  This study is looking at how caring for women during pregnancy can help them get better treatment for opioid use and hepatitis C, making it easier for them to stay in treatment and get the help they need.

  NIH research Boston Medical Center · Boston, United States · NIH-10854925

• Developing a vaccine to protect against hepatitis C virus infection

  This study is testing a new vaccine designed to help protect people from hepatitis C, a virus that can cause serious liver problems, by boosting their immune response to prevent reinfection.

  NIH research Saint Louis University · Saint Louis, United States · NIH-10836046

• Developing quick tests for Hepatitis C infection.

  This study is working on a quick and easy test for doctors to use right away to find out if someone has Hepatitis C, helping patients get the treatment they need faster.

  NIH research Baebies, INC. · Durham, United States · NIH-10683045

• Improving access to hepatitis C treatment in rural Kentucky

  This study is working to make it easier for people in rural Appalachian communities, especially in Perry County, Kentucky, to get treatment for hepatitis C, especially those affected by opioid use, by providing affordable medications and support services to help them access care.

  NIH research University of Kentucky · Lexington, United States · NIH-10671703

• Improving access to hepatitis C treatment for people who inject drugs

  This study is looking at ways to make hepatitis C treatment easier and more effective for people who inject drugs by combining medical care with support for mental health, and it aims to find the best ways to help this group get the care they need.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10669004

• Understanding why some baby boomers with Hepatitis C don't receive effective treatment

  This study is looking into why baby boomers, especially those from different racial and ethnic backgrounds, have a hard time getting treatment for Hepatitis C, and it aims to find ways to make it easier for them to access the care they need.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10630248

Related topics

Quick answers

How many Hepatitis C clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (12 trials), Australia (5 trials), France (2 trials), Iceland (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1/2: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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