Long-term outcomes for patients recovering from hepatitis B related liver failure
The Investigation on Long-term Outcomes and Prognostic Factors of Patients With Hepatitis B Related Acute-on-chronic Liver Failure
This study looks at the long-term health and recovery of people who have survived liver failure caused by hepatitis B to see how they are doing over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Third Affiliated Hospital, Sun Yat-Sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT04310787 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the long-term prognosis and risk factors for patients who have recovered from hepatitis B virus-related acute-on-chronic liver failure. It focuses on patients who survived more than 90 days post-hospitalization and analyzes their clinical data through retrospective methods. Additionally, the study includes follow-up surveys conducted via telephone to gather comprehensive long-term outcome data. The aim is to fill the gap in existing research regarding the long-term survival rates and prognostic factors for these patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 65 who have been diagnosed with hepatitis B associated chronic acute liver failure and survived more than 90 days post-hospitalization.
Not a fit: Patients with HIV infection, liver cancer, autoimmune liver diseases, or other serious conditions that significantly affect survival may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the long-term health outcomes and management strategies for patients recovering from hepatitis B related liver failure.
How similar studies have performed: Previous studies have primarily focused on short-term survival rates, making this investigation into long-term outcomes a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years old; * The diagnosis consistent with hepatitis b associated chronic acute liver failure； * After hospitalization, the survival time \> 90 days； * The inpatient clinical data are complete. Exclusion Criteria: * Human immunodeficiency virus infection or congenital immune deficiency diseases; * Liver cancer and other tumors, autoimmune liver disease, genetic and metabolic liver disease, or other serious diseases that significantly affect patient survival; * Other conditions that the researchers judged not appropriate for inclusion.
Where this trial is running
Guangzhou, Guangdong
- Third Affiliated Hospital of Sun Yat-sen University — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: Liang Peng, Doctor — Third Affiliated Hospital, Sun Yat-Sen University
- Study coordinator: Lu Wang, Doctor
- Email: wanglu910525@163.com
- Phone: +8618814369232
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.