Long-term outcomes for patients recovering from hepatitis B related liver failure
Official title: The Investigation on Long-term Outcomes and Prognostic Factors of Patients With Hepatitis B Related Acute-on-chronic Liver Failure
Run by Third Affiliated Hospital, Sun Yat-Sen University · NCT04310787 · Data updated 2026-11-12
This study looks at the long-term health and recovery of people who have survived liver failure caused by hepatitis B to see how they are doing over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Third Affiliated Hospital, Sun Yat-Sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | May 15, 2020 |
| Main results expected | December 31, 2024 |
| Study ends | December 31, 2024 |
| Registry record updated | November 29, 2024 |
| Trial ID | NCT04310787 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 to 65 who have been diagnosed with hepatitis B associated chronic acute liver failure and survived more than 90 days post-hospitalization.
✕Probably not a fit
Patients with HIV infection, liver cancer, autoimmune liver diseases, or other serious conditions that significantly affect survival may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the long-term prognosis and risk factors for patients who have recovered from hepatitis B virus-related acute-on-chronic liver failure. It focuses on patients who survived more than 90 days post-hospitalization and analyzes their clinical data through retrospective methods. Additionally, the study includes follow-up surveys conducted via telephone to gather comprehensive long-term outcome data. The aim is to fill the gap in existing research regarding the long-term survival rates and prognostic factors for these patients.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the long-term health outcomes and management strategies for patients recovering from hepatitis B related liver failure.
How similar studies have gone: Previous studies have primarily focused on short-term survival rates, making this investigation into long-term outcomes a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years old; * The diagnosis consistent with hepatitis b associated chronic acute liver failure; * After hospitalization, the survival time \> 90 days; * The inpatient clinical data are complete. Exclusion Criteria: * Human immunodeficiency virus infection or congenital immune deficiency diseases; * Liver cancer and other tumors, autoimmune liver disease, genetic and metabolic liver disease, or other serious diseases that significantly affect patient survival; * Other conditions that the researchers judged not appropriate for inclusion.
Where it's running
-
Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Liang Peng, Doctor — Third Affiliated Hospital, Sun Yat-Sen University
- Study coordinator: Lu Wang, Doctor
- Email: wanglu910525@163.com
- Phone: +8618814369232
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study is testing if three antiviral medications can help people with hepatitis B-related liver failure feel better and improve their chances of recovery.
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This project will look back at people with hepatitis B–related ACLF who received MSC infusions to see which factors affect whether the treatment helps.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.