Creating a cohort to study viral RNAs as a new biomarker for hepatitis B cure.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project, known as the CirB-RNA cohort, aims to establish a biological collection of samples and associated clinical data from patients with hepatitis B infection. The focus is on characterizing and quantifying circulating viral RNAs, which may serve as a new biomarker for achieving a functional cure of hepatitis B. Blood samples will be collected from eligible patients during their medical appointments to support this research. The study includes both adults and children over six years old who meet specific criteria related to hepatitis B.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults patients and minor children over 6 years of age (in Lyon) with acute or chronic hepatitis B or presenting with HBsAg loss (with/without HBs seroconversion). (Co-infected patients with HDV and/or HCV and/or HIV are eligible)
* Patients requiring blood sampling for medical care at the time of the medical appointment.
* Informed patients who do not refuse to participate.
* Persons not affiliated to a social security scheme and persons receiving medical assistance from the state may be asked to participate in the study

Exclusion Criteria:

* Patients participating at the time of the inclusion to an interventional trial evaluating a drug likely to interfere with this study.
* Persons deprived of their liberty by a judicial or administrative decision
* Adults who are subject to a legal protection measure
* Children less than 6 years old (in Lyon)

Where it's running

• Hepatology department - Groupement Hospitalier Nord - Hôpital de la Croix-Rousse
  Lyon, France Recruiting
• Hôpital de la Croix-Rousse - Service de maladies infectieuses et tropicales
  Lyon, France Recruiting
• Department of Hepato-gastroenterology and pediatric nutrition - Hôpital Femme-Mère Enfant
  Lyon, France Recruiting
• Gastroenterology and Hepatology department - • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
  Milan, Italy Terminated
• Gastroenterology and Hepatology department - • Università degli Studi di Palermo
  Palermo, Italy Terminated
• Infectious diseases and hepatology unit - Azienda Ospedaliero
  Parma, Italy Terminated

Study contacts

• Study coordinator: Fabien ZOULIM, Pr
• Email: fabien.zoulim@chu-lyon.fr
• Phone: 04 26 10 93 55

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Entecavir 0.5 mg vs 1.0 mg daily in adults with HBV-related decompensated cirrhosis

  This trial tests whether 0.5 mg or 1.0 mg of entecavir once daily can better lower HBV DNA in adults with HBV-related decompensated cirrhosis over 24 weeks.

  Recruiting Phase 4 Bangladesh Medical University · Dhaka, Dhaka Division · NCT07816094

• Hepatitis B in Zambia: an observational cohort of adults with HBV, with or without HIV

  This observational cohort follows adults diagnosed with hepatitis B in Zambia, with and without HIV coinfection, to see how their liver disease and HBV (and HIV when present) change over several years while they receive standard care.

  Recruiting at 3 sites University of Alabama at Birmingham · Lusaka and 2 other locations · NCT07589985

• Long-term outcomes of pegylated interferon alfa-2b in families with clustered hepatitis B and high risk of cirrhosis or liver cancer

  This study will try pegylated interferon alfa-2b to see if it improves long-term outcomes for people with chronic hepatitis B from families where cirrhosis or liver cancer affects two generations.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi and 1 other locations · NCT07079150

• Comparing two treatments to prevent hepatitis B transmission from mothers to infants

  This study is testing whether two different antiviral treatments can help prevent pregnant women with high hepatitis B levels from passing the virus to their babies.

  Recruiting Guangzhou 8th People's Hospital · Guangzhou, Guangdong and 9 other locations · NCT06947356

• Untreated or Unknown HBV, HDV, and HCV in South-East Austria: See if People Need Care

  This study looks at past test results to see how many people in South-East Austria have hepatitis B, hepatitis D coinfection, or hepatitis C that hasn’t been treated yet or isn’t known, and then invites them for care.

  Recruiting Medical University of Graz · Graz, Styra · NCT06834178

• Monoclonal antibody treatment for chronic hepatitis B

  This study is testing a new monoclonal antibody treatment for people with chronic hepatitis B to see if it can help clear the virus and possibly allow them to stop their long-term antiviral medications.

  Recruiting Phase 1 University of Aarhus · Aarhus N · NCT06668727

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.