HBV cure factors in people with and without HIV
Official title: Immune response dynamics and hepatitis B cure in persons with and without HIV infection
Funded at Johns Hopkins University · NIH-11600298 · Data updated 2026-11-12
This project studies how HBV-specific immune cells behave during treatment and whether people with HIV respond differently than those without HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 17, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $5,184 |
| NIH project number | 3U19AI188551-02S1 |
| Project ID | NIH-11600298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+ years) with HBV infection, including those living with HIV and chronic HBV, initiating NUC therapy.
✕Less likely to help
Individuals not starting NUC therapy or without HBV infection.
What this research studies
Researchers will track HBV-specific B and T cell responses in a diverse, multinational group of adults starting nucleos(t)ide analog therapy for HBV, including people living with HIV. By comparing those with HBV alone to those with HIV co-infection, the study aims to identify immune patterns associated with achieving HBV cure. Blood samples from sites in Uganda, Brazil, India, Senegal, and the United States will be analyzed to capture responses across major HBV genotypes. The findings could reveal why some people clear the virus and how HIV may influence this process. The work will help guide future therapies and personalized strategies for achieving HBV cure in diverse patient populations.
Why it matters
Potential benefit: Understanding immune signatures of HBV cure could lead to more effective, personalized treatments for people with HBV, with or without HIV.
How similar studies have gone: Prior studies have linked HBV-specific immune responses to cure, but this multi-genotype, HIV-coinfected cohort approach is novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Thio, Chloe L — Johns Hopkins University
- Study coordinator: Thio, Chloe L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.