Condition

Chronic Hepatitis B clinical trials and research

• 45Clinical trials
• 11NIH research projects
• 9Countries

Newest Chronic Hepatitis B clinical trials

All recruiting trials (45)

• Impact of functional cure on patient-reported outcomes in chronic hepatitis B

  This study tests whether people with chronic hepatitis B who achieve a functional cure have better patient-reported outcomes compared to those not cured, relapse, or healthy controls.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou · NCT07855029

• Sequential combination therapy for functional cure of chronic hepatitis B

  This trial tests a new two-drug approach to see if adding immunotherapy to ongoing HBV treatment can lead to loss of hepatitis B surface antigen in adults with chronic hepatitis B.

  Recruiting Phase 2 The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT07852091

• Combination therapy for functional cure in chronic hepatitis B

  This phase 2 trial tests whether a sequence of anti-PD-1/PD-L1 antibodies with pegylated interferon and nucleos(t)ide analogues can achieve functional cure (HBsAg loss) in adults with chronic hepatitis B.

  Recruiting Phase 2 The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT07845058

• GST-HG131/GST-HG141 tablets vs placebo in chronic hepatitis B

  A phase IIa trial tests GST-HG131 and GST-HG141 tablets against placebo to see if they are safe and help people with chronic hepatitis B.

  Recruiting Phase 2 Fujian Akeylink Biotechnology Co., Ltd. · Beijing · NCT07709520

• AHB-137 injection in people with chronic hepatitis B

  This study tests AHB-137 vs placebo in adults with chronic hepatitis B who have not yet received antiviral treatment.

  Recruiting at 34 sites Phase 2 Ausper Biopharma Co., Ltd. · Beijing, Beijing Municipality and 33 other locations · NCT07635186

• AHB-137 injection pharmacokinetics and safety in people with mild to moderate liver dysfunction and normal liver function

  This study tests how AHB-137 behaves in the body and its safety in adults with chronic hepatitis B who have mild to moderate liver problems or normal liver function.

  Recruiting Phase 1 Ausper Biopharma Co., Ltd. · Chongqing, Chongqing Municipality and 4 other locations · NCT07600788

• ASC22 plus pegylated interferon alfa to try to achieve a functional cure for chronic hepatitis B

  This trial tests whether adding ASC22 (an anti–PD‑L1 antibody) to pegylated interferon alfa with background antiviral pills can help adults with HBeAg‑negative chronic hepatitis B and very low viral markers reach a functional cure.

  Recruiting Phase 4 The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT07573943

• HBVCare: See if a mobile app helps adults with chronic hepatitis B stick to treatment

  This trial tests whether using the HBVCare mobile app helps adults with chronic hepatitis B take their medication and attend follow-up visits more reliably.

  Recruiting at 2 sites Institute of Gastroenterology and Hepatology, Vietnam · Hanoi and 1 other locations · NCT07540637

• Adaptability of an Undetectable = Untransmissible Model for Hepatitis B

  This study tests whether very low or undetectable HBV levels in people with chronic hepatitis B mean they are unlikely to transmit the virus to others.

  Recruiting NYU Langone Health · New York, New York · NCT07449091

• Azvudine tablets to promote clinical cure in people with chronic hepatitis B.

  This trial tests whether azvudine tablets can help achieve clinical cure in adults with chronic hepatitis B who are HBeAg-positive, have high viral load and elevated ALT, and have not received prior antiviral treatment.

  Recruiting Phase 3 The First Affiliated Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07307586

• SA1211 injection safety and dosing in people with chronic hepatitis B and healthy volunteers

  This trial will test whether one or multiple under-the-skin injections of SA1211 are safe, trigger immune responses, and show early signs of benefit in adults with chronic hepatitis B and in healthy volunteers.

  Recruiting Phase 1 Suzhou Siran Biotechnology Co.,Ltd. · Changchun, Jilin · NCT07275918

• Bacteroides fragilis plus branched-chain amino acids to help clear HBsAg

  This project tests whether adding Bacteroides fragilis and branched-chain amino acids to routine antiviral therapy helps people with chronic hepatitis B clear HBsAg.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT07257562

• Reducing liver cancer risk in people with chronic hepatitis B — Zhiyuan Project

  This project will follow adults with chronic hepatitis B who are receiving common antiviral or pegylated interferon treatments to see if different therapies affect liver cancer risk and other long-term outcomes.

  Recruiting at 162 sites The First Affiliated Hospital of Zhengzhou University · Anyang and 161 other locations · NCT07169656

• Long-term follow-up of people with chronic hepatitis B after AHB-137 injection

  This follow-up will see how long viral control lasts in people with chronic hepatitis B who had a complete or partial response to AHB-137 injection.

  Recruiting at 8 sites Ausper Biopharma Co., Ltd. · Hefei, Anhui and 36 other locations · NCT07146100

• AHB-137 injection for adults with chronic hepatitis B previously treated with nucleos(t)ide analogue antivirals

  This will test whether AHB-137 injection improves viral control and liver function in adults with chronic hepatitis B who were previously treated with nucleos(t)ide analogue antivirals.

  Recruiting at 4 sites Phase 2 Ausper Biopharma Co., Ltd. · Beijing, Beijing Municipality and 11 other locations · NCT07137910

• GST-HG141 for people with chronic hepatitis B who have not had an adequate response to antiviral treatment

  This trial will test whether adding GST-HG141 helps people with chronic hepatitis B who still have detectable virus despite at least a year on standard antiviral medication.

  Recruiting Phase 3 Fujian Akeylink Biotechnology Co., Ltd. · Hangzhou, Zhejiang · NCT07090759

• AHB-137 in combination with hepatitis B drugs for chronic hepatitis B

  This phase 2 study tests whether AHB-137 given with other HBV medicines can help people with chronic hepatitis B who are already on antiviral therapy.

  Recruiting at 14 sites Phase 2 Ausper Biopharma Co., Ltd. · Beijing, Beijing Municipality and 13 other locations · NCT07069569

• Hospital-based program to improve care for people with chronic hepatitis B

  This project tests whether hospital screening, automated alerts, and a dedicated referral pathway can increase referrals, treatment starts, and follow-up for people with chronic hepatitis B identified outside liver or infectious disease clinics.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong and 2 other locations · NCT06966908

• HBV-specific T-cell therapy for chronic hepatitis B patients

  This study is testing a new treatment using modified T-cells to see if it can help people with chronic hepatitis B feel better and fight the virus more effectively.

  Recruiting Phase 1 Changhai Hospital · Shanghai · NCT06885710

• Research on recovery and maintenance strategies for chronic hepatitis B

  This study is testing different treatment strategies for people with chronic hepatitis B to see how well they help manage the condition and prevent liver problems.

  Recruiting Beijing Municipal Administration of Hospitals · Beijing, Beijing Municipality · NCT06803368

• Understanding Hepatitis B Virus Characteristics and Resistance

  This study looks at people with chronic hepatitis B to see how the virus behaves and if it has any resistance to treatments, by comparing those on medication to those not receiving treatment.

  Recruiting Beijing Friendship Hospital · Beijing, Beijing Municipality · NCT06779864

• Using MR elastography to assess liver fibrosis in chronic hepatitis B patients

  This study is testing if a new imaging technique called MR elastography can help doctors better understand liver damage in adults with chronic hepatitis B without needing a liver biopsy.

  Recruiting Shengjing Hospital · Shenyang, Liaoning · NCT06779058

• Exploring genetic factors in chronic hepatitis B treatment with pegylated interferon-α

  This study is trying to see if certain genetic factors can help predict how well chronic hepatitis B patients will respond to treatment with pegylated interferon-α.

  Recruiting Beijing Municipal Administration of Hospitals · Beijing, Beijing Municipality · NCT06696664

• Evaluating Tune-401 for safety and effectiveness in adults with Chronic Hepatitis B

  This study is testing a new drug called Tune-401 to see if it is safe and effective for adults with Chronic Hepatitis B.

  Recruiting at 3 sites Phase 1 Tune Therapeutics, Inc. · Hong Kong and 2 other locations · NCT06671093

• Hepatitis D in people with chronic hepatitis B in Vietnam

  This observational study tests how common hepatitis D is among people with chronic hepatitis B and looks at the types of HDV and related factors.

  Recruiting at 3 sites Tam Anh Research Institute · Hà Nội, Northern Vietnam and 2 other locations · NCT06638320

• TherVacB: a two-part therapeutic hepatitis B vaccine with a protein prime and MVA boost

  In people with chronic hepatitis B who are already virally suppressed on antiviral pills, this study tests a two-dose protein vaccine followed by an MVA booster to see if it can safely trigger an immune response.

  Recruiting at 5 sites Phase 1/2 Ludwig-Maximilians - University of Munich · Frankfurt and 5 other locations · NCT06513286

• Evaluating HRS-5635 Injection for Chronic Hepatitis B Treatment

  This study is testing if an injection called HRS-5635 can help people with chronic hepatitis B feel better when used alone or with other treatments.

  Recruiting Phase 2 Fujian Shengdi Pharmaceutical Co., Ltd. · Guangzhou, Guangdong · NCT06425341

• Antiviral therapy for chronic hepatitis B with nonalcoholic fatty liver disease

  This study is testing if a new antiviral treatment can help people with chronic hepatitis B and fatty liver disease clear the virus better than the standard medication.

  Recruiting at 5 sites Phase 4 First Affiliated Hospital of Wenzhou Medical University · Ningbo and 4 other locations · NCT06368882

• Using dapagliflozin to prevent liver complications in patients with chronic hepatitis B and diabetes

  This study is testing if the diabetes medication dapagliflozin can help prevent liver problems in people with chronic hepatitis B and diabetes.

  Recruiting Phase 4 Chinese University of Hong Kong · Hong Kong · NCT06364930

• Pegylated interferon treatment for chronic hepatitis B patients who previously received interferon

  This study is testing if a new pegylated interferon treatment can help people with chronic hepatitis B who didn't get better with previous interferon therapy.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06323681

• Investigating the use of terbinafine for chronic hepatitis B patients

  This study is testing if the antifungal drug terbinafine can help people with chronic hepatitis B by reducing the virus in their liver and improving their liver health.

  Recruiting Phase 1/2 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06295328

• Evaluating GST-HG131 tablets for chronic hepatitis B

  This study is testing if GST-HG131 tablets can help people with chronic hepatitis B feel better compared to a placebo.

  Recruiting Phase 2 Fujian Akeylink Biotechnology Co., Ltd. · Beijing · NCT06263959

• Effects of Imdusiran on Chronic Hepatitis B

  This study is testing if a new drug called Imdusiran can improve treatment for adults with chronic hepatitis B who are already taking antiviral medication.

  Recruiting Phase 2 University of Maryland, Baltimore · Baltimore, Maryland · NCT06154278

• Evaluating the HBV Reservoir and Immunological Characteristics in Chronic Hepatitis B Patients

  This study is trying to understand how the hepatitis B virus hides in the liver and affects the immune system in people with chronic hepatitis B to help find better treatments.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06047093

• Using tenofovir alafenamide (TAF) in pregnancy to prevent mother-to-child hepatitis B transmission

  This study will try giving tenofovir alafenamide (TAF) to pregnant women with high hepatitis B viral loads to see if it safely lowers virus levels and prevents passing HBV to their babies.

  Recruiting Phase 4 First People's Hospital of Hangzhou · Hangzhou, Zhejiang · NCT05853718

• Combination of peg‑IFNα and an anti‑PD‑1 antibody plus antiviral therapy to try to cure chronic hepatitis B

  This phase 2 test will try adding an anti‑PD‑1 antibody to peg‑IFNα and nucleos(t)ide therapy to see if it produces sustained HBsAg loss in adults with chronic hepatitis B.

  Recruiting Phase 2 The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT05771402

• Anti‑PD‑1 plus antivirals and interferon to try for sustained HBsAg loss in chronic hepatitis B

  This trial will try adding an anti‑PD‑1 antibody to standard nucleos(t)ide antivirals (with sequential interferon in some patients) to see if more adults with chronic hepatitis B can achieve sustained HBsAg loss.

  Recruiting Phase 2 The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT05769816

• Investigating risk factors for liver inflammation and fibrosis in patients with chronic hepatitis B and non-alcoholic fatty liver disease

  This study is trying to find out what factors can increase the risk of liver inflammation and scarring in people with chronic hepatitis B and non-alcoholic fatty liver disease.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing · NCT05766449

• Observing outcomes in patients with chronic hepatitis B in an indeterminate phase

  This study is trying to learn more about patients with chronic hepatitis B who are in a tricky stage of their illness to see how their condition changes and if they might need treatment.

  Recruiting at 5 sites The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Changzhou, Jiangsu and 4 other locations · NCT05661786

• Using Tenofovir Alafenamide to Prevent Hepatitis B Transmission from Mother to Child

  This study is testing if a new medication called Tenofovir Alafenamide can safely help pregnant women with Hepatitis B prevent passing the virus to their babies.

  Recruiting The Third Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT05466071

• Long-term outcomes of antiviral therapies for chronic hepatitis B

  This study is testing how well two different antiviral treatments for chronic hepatitis B work over five years to see if they help prevent serious liver problems.

  Recruiting Huashan Hospital · Shanghai · NCT04896255

• HEPLISAV-B (TLR‑9 adjuvanted) vaccine for adults with chronic hepatitis B

  This trial will try giving two HEPLISAV-B vaccine shots to adults with chronic hepatitis B who are virally suppressed on antiviral therapy to see if the vaccine is safe and how it affects their immune cells.

  Recruiting Phase 1 University of Maryland, Baltimore · Baltimore, Maryland · NCT04843852

• Stopping antiviral treatment for chronic hepatitis B patients

  This study is testing if people with chronic hepatitis B can safely stop their antiviral medication after being stable for over a year and still maintain good health outcomes.

  Recruiting Phase 4 Humanity & Health Medical Group Limited · Hong Kong, Hong Kong SAR · NCT03792919

• Observing effects after stopping hepatitis B treatment

  This study looks at what happens to people with chronic hepatitis B after they stop their treatment to see how their health changes over time.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT02883647

• Monitoring chronic hepatitis B patients with fatty liver disease

  This study looks at how chronic hepatitis B affects people who also have fatty liver disease to see if having both conditions leads to more serious liver problems over time.

  Recruiting Humanity and Health Research Centre · Hong Kong, Hong Kong · NCT02863757

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• HBV immune responses in functional cure and therapies guided by CD4 T cells and B cells

  This grant studies how HBV-specific CD4 T cells and B cells behave in people with hepatitis B to identify clues for achieving a functional cure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11418540

• Therapeutic nucleic acid vaccine for chronic hepatitis B in people with HIV/HBV co-infection

  A new genetic vaccine approach is being tested to help people living with both HIV and chronic hepatitis B reduce and potentially cure their HBV infection.

  NIH research Orlance, INC. · Seattle, United States · NIH-11415128

• HBV immune responses and pathways linked to functional cure

  Researchers will study how HBV-specific CD4 T cells and B cells behave in people with chronic hepatitis B to find what immune changes are needed for a functional cure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11414993

• Nanobodies to help clear HBV surface antigen and restore immunity

  A small, targeted antibody therapy using nanobodies is being explored to lower hepatitis B surface antigen in people with chronic HBV, with the goal of helping the immune system clear the infection.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11391645

• How immune cells help control chronic hepatitis B

  This research looks at how two immune cell types (CD4 T cells and B cells) in adults with hepatitis B act differently in people who clear the virus versus those with long-term infection to find clues for treatments that could lead to a functional cure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11388070

• Host-targeted antiviral to achieve a functional cure for chronic hepatitis B

  A research project tests a new drug strategy that aims to clear signs of hepatitis B in people who have a chronic infection.

  NIH research Evrys Bio, INC. · Doylestown, United States · NIH-11364197

• Long-acting injectable hepatitis B antivirals with an immune booster

  This project is developing long-lasting injectable hepatitis B medicines combined with an immune stimulant for people living with chronic hepatitis B.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11317188

• A new antiviral medicine for chronic hepatitis B that aims for a complete cure

  This project is creating a new medicine to help people with chronic hepatitis B achieve a lasting cure, rather than just controlling the infection.

  NIH research Evrys Bio, LLC · Doylestown, United States · NIH-11141017

• Developing a new treatment to potentially cure chronic hepatitis B

  This study is testing a new type of medicine that targets the hepatitis B virus to help people with chronic hepatitis B by potentially lowering the virus levels in their bodies and improving their health.

  NIH research Evrys Bio, LLC · Doylestown, United States · NIH-11049505

• New treatments for chronic hepatitis B using long-acting medications

  This study is testing a new type of long-lasting injection for people with chronic hepatitis B that could replace daily pills, making treatment easier and more effective by combining special medications to help your body fight the virus.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11042702

• Developing a new drug to cure chronic hepatitis B virus infection

  This study is working on a new antiviral medicine to help people with chronic hepatitis B, and if you join, you could help test how well it works and if it's safe, which could lead to better treatment options for everyone dealing with this condition.

  NIH research Hbvtech · Germantown, United States · NIH-10821260

Related topics

Quick answers

How many Chronic Hepatitis B clinical trials are recruiting right now?

45, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in China (34 trials), Hong Kong (3 trials), United States (3 trials), Vietnam (2 trials), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Phase 4: 5, Phase 1: 5, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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