HBV cure clues in people with and without HIV

Who could benefit from this research

What this research studies

Researchers will analyze longitudinal blood samples from a diverse, multi-country group starting HBV treatment to see how HBV-specific immune cells behave in people with HIV compared to those without. They will examine HBV B cells and T cells across major HBV genotypes from Uganda, Brazil, India, Senegal, and the United States to understand how genetic differences affect immune responses. The study aims to link the strength and variety of antibody responses to achieving HBV cure during nucleos(t)ide analogue therapy. Findings could reveal why some people clear HBV and how HIV co-infection changes this process. The work is conducted at Johns Hopkins University with international collaborators over several years.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Thio, Chloe L — Johns Hopkins University
• Study coordinator: Thio, Chloe L

Related research

Other NIH-funded projects on the same topics.

• HBV cure factors in people with and without HIV

  This project studies how HBV-specific immune cells behave during treatment and whether people with HIV respond differently than those without HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11600298

• HBV cure signals in people with and without HIV

  This project studies how HBV-specific immune responses differ in people with HIV compared to those without HIV who are being treated for hepatitis B, with the aim of understanding what parts of the immune system help achieve a cure.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11419816

• Understanding how genetic changes in blood cells relate to heart disease in people with HIV

  A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11642564

• Cardiac health and protein markers in kids with perinatal HIV exposure or infection

  A study from Duke aims to understand heart health and protein biomarkers in children who were exposed to or infected with HIV at birth, especially in sub-Saharan Africa.

  NIH research Duke University · Durham, United States · NIH-11611413

• Myocardial fibrosis and fat in ART-treated women with HIV in sub-Saharan Africa

  This project studies heart tissue changes in women with HIV in sub-Saharan Africa who are on antiretroviral therapy, to understand why they’re at higher risk for heart problems as they age.

  NIH research University of Washington · Seattle, United States · NIH-11594185

• Myocardial fibrosis and fat in ART-treated women with HIV in sub-Saharan Africa

  This grant studies heart tissue changes in women living with HIV in sub-Saharan Africa to understand why heart failure risk is higher in this group.

  NIH research University of Washington · Seattle, United States · NIH-11594184

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.