HBV and HIV Cure Cohort for a Functional HBV Cure
Official title: Hepatitis B and HIV Cure Consortium (BICC)
Funded at Johns Hopkins University · NIH-11423431 · Data updated 2026-11-12
A multinational group will enroll people living with HIV and chronic hepatitis B to study new technologies that could lead to a functional cure for HBV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 17, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $265,462 |
| NIH project number | 3U19AI188551-02S3 |
| Project ID | NIH-11423431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV who also have chronic hepatitis B, along with specific eligibility criteria defined by the study protocol.
✕Less likely to help
Individuals not meeting the eligibility criteria or not willing to undergo liver biopsies or serial blood draws may not experience direct benefit.
What this research studies
This project will enroll a diverse group of adults living with HIV and chronic hepatitis B across multiple countries to collect clinical data and samples. Researchers will build a clinical and specimen repository and apply novel technologies to understand what factors influence loss of hepatitis B surface antigen (HBsAg) without ongoing treatment. The study involves semi-annual visits with blood draws and liver biopsies for a subset to analyze immune responses and viral markers. The goal is to identify pathways and biomarkers that could enable a functional cure for HBV, with results informing future therapies for people affected by both infections.
Why it matters
Potential benefit: If successful, the project could accelerate development of therapies leading to durable HBV control or cure for people living with HIV and chronic hepatitis B.
How similar studies have gone: Previous cohorts and biorepositories have advanced understanding of HBV in co-infected populations, though this project emphasizes new technologies and international genotype diversity.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Thio, Chloe L — Johns Hopkins University
- Study coordinator: Thio, Chloe L
Related research
Other NIH-funded projects on the same topics.
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HBV cure clues in people with and without HIV
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This project will use immune-related blood markers to find liver cancer earlier in people with chronic hepatitis B, focusing on Hispanic adults.
-
HBV safety with long-acting HIV therapy for people with HIV
A study to understand how long-acting HIV meds affect hepatitis B in people living with HIV and how to best monitor and protect them.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.