Condition

Fatty Liver clinical trials and research

• 19Clinical trials
• 103NIH research projects
• 12Countries

Newest Fatty Liver clinical trials

All recruiting trials (19)

• Metabolic Liver Disease in People Newly Diagnosed with HIV

  This study tests whether HIV-infected adults who are starting ART are more likely to develop MASLD and related liver issues than HIV-negative adults over five years.

  Recruiting at 11 sites Guven Health Group · Ankara, Ankara and 10 other locations · NCT07737340

• Peanut intake and liver health in adults with MASLD

  This study tests whether adding peanuts to daily meals for 12 weeks can improve liver markers and metabolic health in adults with MASLD.

  Recruiting Henry Ford Health System · Detroit, Michigan · NCT07646197

• Photon-counting CT and ultrasound for detecting liver fat and scarring

  This will test whether a new photon-counting CT plus ultrasound can find liver fat and scarring in adults with fatty liver or liver fibrosis, using MRI as the reference.

  Recruiting Duke University · Durham, North Carolina · NCT07495332

• Erdosteine for nonalcoholic fatty liver disease

  This trial will try erdosteine alongside standard therapy in adults with nonalcoholic fatty liver disease confirmed by ultrasound to see if it improves liver fat and liver health.

  Recruiting Phase 1/2 Tanta University · Tanta · NCT07242222

• Cilostazol for nonalcoholic fatty liver disease.

  This trial will test whether the medicine cilostazol can reduce liver fat and improve liver health in adults with nonalcoholic fatty liver disease.

  Recruiting Phase 1/2 Tanta University · Damietta, New Damietta · NCT07238985

• Gepaktiv compared with UDCA and Ademetionine for MAFLD with enlarged liver

  This study will try the dietary supplement Gepaktiv to see if it improves liver enzymes, liver size, and fat in adults with MAFLD and hepatomegaly compared with UDCA and ademetionine.

  Recruiting Phenomen Pharma · Tyumen, Tyumen Oblast · NCT07068191

• Combining pioglitazone and empagliflozin for treating fatty liver disease in type 2 diabetes

  This study is testing if using two diabetes medications together can help people with type 2 diabetes and fatty liver disease improve their liver health more than using either medication alone.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si · NCT06989723

• Ultraportable Hepatoscope ultrasound for measuring liver fat in MASLD/MASH

  The Hepatoscope device will be tested to see if it can measure liver fat accurately in adults with MASLD/MASH compared with MRI-PDFF.

  Recruiting at 2 sites E-Scopics · Angers and 2 other locations · NCT06661655

• Evaluating Nicotinamide for Liver Fibrosis in Type 2 Diabetes Patients

  This study is testing if a supplement called nicotinamide can help people with type 2 diabetes and liver scarring feel better and improve their liver health.

  Recruiting Phase 2 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT06599918

• Investigating heart problems in patients with fatty liver disease

  This study looks at how fatty liver disease might affect heart health in adults aged 18-65 by checking for heart problems like coronary artery disease and heart failure.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh, Chandigarh · NCT06386094

• Analyzing ELF Test for Early Detection of Fatty Liver in High-Risk Patients

  This study is testing if a new liver test can help find early signs of fatty liver disease in people at high risk, like those with metabolic syndrome, and see how lifestyle changes or medications affect their liver health over time.

  Recruiting Methodist Health System · Dallas, Texas · NCT06225193

• Monitoring liver fat changes using a new technology

  This study is testing a new way to track changes in liver fat over time for people with non-alcoholic fatty liver disease to see if it works as well as the current method using MRI.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06203548

• Impact of CoQ10 on patients with fatty liver disease

  This study is testing if taking high doses of CoQ10 can help people with fatty liver disease feel better by reducing inflammation and improving their health markers.

  Recruiting Phase 2 Ain Shams University · Cairo · NCT05984745

• Intermittent fasting to treat fatty liver disease in non-obese adults

  This study is testing if intermittent fasting can help non-obese adults with fatty liver disease improve their liver health and overall well-being.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04899102

• Non-invasive tool to predict fatty liver disease

  This study is testing a new, non-invasive tool to see if it can help identify fatty liver disease in healthy people and those already diagnosed with it.

  Recruiting Richmond Pharmacology Limited · London, London · NCT04873258

• Observational cohort for non-alcoholic fatty liver disease and related conditions

  This study is trying to learn more about non-alcoholic fatty liver disease and its related conditions by looking at patients with different stages of the disease and comparing them to people with diabetes and obesity who don't have it.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, Rome/lazio/italy · NCT04371042

• Testosterone Undecanoate's effects on liver fat in overweight men with diabetes

  This study is testing if a testosterone treatment can help reduce liver fat in overweight men with type 2 diabetes and low testosterone levels.

  Recruiting Phase 4 Medical University of Vienna · Vienna · NCT03851627

• Tracking health factors in pregnant women and their children

  This study looks at how the health and lifestyle of pregnant women from American Indian/Alaska Native and Hispanic backgrounds affect their children's growth and risk of obesity as they grow up.

  Recruiting National Institutes of Health Clinical Center (CC) · Phoenix, Arizona · NCT03481829

• Biorepository for liver disease samples

  This study is collecting samples from patients with liver diseases to help researchers find better treatments and improve care for these conditions.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT03025074

NIH-funded research (newest 40 of 103)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Role of fat droplets in liver fat and inflammatory signals in NAFLD

  A study at Johns Hopkins will explore how fat droplets in the liver influence molecules that drive inflammation and progression of non-alcoholic fatty liver disease (NAFLD) in adults.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11623263

• Them1 Inhibitors to Help Treat Fatty Liver Disease

  Aims to develop and test small molecule drugs that block Them1 to help people with non-alcoholic fatty liver disease (NAFLD).

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11519341

• How the TET1 gene affects non-alcoholic fatty liver disease

  Researchers are looking at whether changes in the TET1 gene and DNA 'tagging' (methylation) play a role in adult non-alcoholic fatty liver disease.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11447065

• Hepatocellular Genetic Clues for Fatty Liver in Hispanic Adults

  A large NIH grant helps researchers study why fatty liver develops in Hispanic adults and how genetics interact with lifestyle to affect risk.

  NIH research University of Texas Rio Grande Valley · Edinburg, United States · NIH-11421441

• Toxic fats, vitamin B12 loss, and AHR may drive fatty liver disease

  This grant looks at how certain environmental chemicals may trigger liver damage linked to fatty liver disease and how a vitamin found in the blood could be affected.

  NIH research Michigan State University · East Lansing, United States · NIH-11398883

• Glutamine and T cells in fatty liver disease

  A study explores how liver glutamine levels affect inflammatory CD4+ T cells in fatty liver disease to find potential new ways to reduce liver inflammation.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11388863

• PNPLA3 gene and fatty liver disease risk and protection

  A doctor-scientist team is studying why some people develop fatty liver disease and others don’t, focusing on a gene variant called PNPLA3 and how it affects people of different ancestries.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11386433

• Targeting fatty liver disease in women around pregnancy to improve health

  This grant explores how to identify and help pregnant and postpartum women who are at risk for fatty liver disease to prevent liver problems later.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11385949

• Social factors and fatty liver disease disparities across diverse communities

  A research project will look at how where people live and their social circumstances influence fatty liver disease and why it hits some racial/ethnic groups harder.

  NIH research Drexel University · Philadelphia, United States · NIH-11381709

• Comparing cost-effective ways to prevent liver cancer in MAFLD

  This grant looks at which prevention strategies for liver cancer in people with MAFLD give the best value for patients and the health system.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11379132

• Adipokine could help reverse fatty liver and NASH in adults

  A new adipokine from fat tissue may rapidly reduce liver fat and inflammation in adult patients with nonalcoholic fatty liver disease and NASH, using mouse models to study how it works.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11374890

• One MRI scan that measures liver fat, iron, and scarring

  A new MRI method uses a single scan to measure liver fat, iron, and scarring for people with nonalcoholic fatty liver disease.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11372037

• Clinically meaningful research on fatty liver disease in adults and children

  A nationwide effort studying MASLD, the major form of fatty liver disease, to find better ways to identify who is at risk and how to treat it, including kids and adults.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11369254

• Synergy between liver tissue environment and cell interactions in fatty liver disease

  A patient-facing overview of a project exploring how liver cells communicate and respond to their surroundings in non-alcoholic fatty liver disease to identify new ways to treat fibrosis.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11360197

• Role of Lipocalin Prostaglandin D2 Synthase (L-PGDS) and PGD2 in NAFLD

  A research project explores whether a specific liver enzyme and its product influence the development of non-alcoholic fatty liver disease (NAFLD).

  NIH research St. John's University · Queens, United States · NIH-11353996

• NAFLD in PCOS: Do androgens drive liver injury and fatty liver progression?

  Young women with PCOS may face liver disease progression due to high androgen levels, and this research looks at targeted ways to slow or prevent that progression.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11345167

• Re-engineering a human 3D liver tissue model to screen drugs for fatty liver disease

  A research project is creating a human-like 3D liver model to test drugs for non-alcoholic fatty liver disease in adults.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11345128

• Ultrasound tests to find and track fatty liver in children

  This project develops easy-to-use ultrasound methods to find and monitor liver fat in children who are overweight or obese.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11326290

• How a liver immune protein (SMPDL3B) affects fatty liver in people with obesity

  This project looks at whether restoring a liver immune protein called SMPDL3B can reduce inflammation and slow fatty liver disease in people with obesity.

  NIH research University of Kentucky · Lexington, United States · NIH-11325730

• How redox balance and a sugar tag (O-GlcNAc) affect alcohol-related fatty liver

  Researchers are examining whether changes in liver oxidative balance and a protein sugar tag called O-GlcNAc influence fat buildup in people who drink alcohol.

  NIH research Yale University · New Haven, United States · NIH-11324191

• Skin markers for fatty liver in kids and young adults

  This project tests whether a quick, painless skin sample can help find fatty liver disease in children and young adults with obesity.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11323027

• How genes and heavy metals influence fatty liver disease

  This project looks at how a person’s genes and the amounts of metals in their liver together relate to nonalcoholic fatty liver disease (NAFLD).

  NIH research Wayne State University · Detroit, United States · NIH-11306089

• Human lab-grown livers to find medicines for metabolic fatty liver disease

  This project uses computer models and tiny human liver tissues grown from stem cells to find medicines that could help people with metabolic fatty liver disease linked to specific genes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11290358

• Sex differences in liver cells and fatty liver disease

  This project looks at how male and female livers differ at the cell level and how those differences relate to fatty liver disease in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11257684

• Liver protein TMEM141 and non-alcoholic fatty liver disease

  This project looks at whether a liver protein called TMEM141 changes bile acid balance and the development of non-alcoholic fatty liver disease (NAFLD), with implications for people with NAFLD.

  NIH research University of Arizona · Tucson, United States · NIH-11257328

• Gm4951 gene and nonalcoholic fatty liver disease (NAFLD)

  Researchers are looking at whether changes in the Gm4951 gene affect how much fat builds up in the liver for people with nonalcoholic fatty liver disease.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11248812

• Investigating the link between fatty liver disease and preeclampsia risk in pregnant women

  This study is looking at how nonalcoholic fatty liver disease might increase the chances of developing preeclampsia in overweight and obese pregnant women, with the goal of finding ways to keep moms and babies healthier during pregnancy.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11248108

• Liver energy imbalance (NADH) and the driver ChREBP in fatty liver and high blood fats

  This project aims to lower a liver chemical called NADH to see if that reduces liver fat and improves blood fat levels for people with alcoholic or non-alcoholic fatty liver disease.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11247909

• How bile acids control fat absorption and fatty liver

  This project looks at whether changing liver bile acid genes can lower harmful fat buildup in people with or at risk for non-alcoholic fatty liver disease.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11233245

• Preventing and treating fatty liver during pregnancy and after childbirth

  This project screens pregnant and postpartum women for fatty liver using blood tests and non-invasive tools to track liver changes that could affect their long-term health.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11228037

• How the StarD5 cholesterol transporter affects fatty liver disease

  This project looks at whether a protein called StarD5 that moves cholesterol inside liver cells helps cause or prevent fatty liver disease.

  NIH research VA Veterans Administration Hospital · Richmond, United States · NIH-11213944

• Understanding a natural substance to help fatty liver disease

  This research explores how a natural substance found in fat tissue might help reduce liver fat and inflammation in people with nonalcoholic steatohepatitis, or NASH.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11180257

• Why non-alcoholic fatty liver disease turns into liver cancer or other serious problems

  The team will look for biological and environmental factors in adults with non-alcoholic fatty liver disease that make the condition progress to liver cancer or end-stage liver disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11178421

• Diet, metabolism, and fatty liver in Hispanic/Latino adults

  Researchers are looking at how diet and metabolic products relate to fatty liver disease in Hispanic/Latino adults.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11166690

• Understanding and Treating Fatty Liver Disease

  This project aims to find better ways to understand, diagnose, and treat fatty liver disease, which affects many adults and children.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11166644

• Understanding a protein's role in non-alcoholic fatty liver disease

  This project explores how a specific protein and its byproduct might contribute to non-alcoholic fatty liver disease, hoping to find new ways to help people with this condition.

  NIH research St. John's University · Queens, United States · NIH-11166340

• Investigating how lipid droplet proteins affect liver disease and inflammation

  This study is looking at how certain proteins in fat droplets affect the way our bodies handle fats and how this relates to non-alcoholic fatty liver disease (NAFLD), and it may involve patients helping to find out if their genes play a role in their liver health.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11162453

• Preventing Liver Cancer in People with Fatty Liver Disease

  This project looks at the best and most affordable ways to prevent liver cancer in people who have fatty liver disease.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11146345

• Understanding how calcium signaling affects fatty liver disease

  This study is looking at how calcium levels in liver cells are affected by high-fat diets and how this might lead to non-alcoholic fatty liver disease and diabetes, with the hope of finding new ways to help people who are dealing with these conditions.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11141604

• How the PNPLA3 gene affects who gets fatty liver and who is protected

  This research looks at how changes in the PNPLA3 gene influence the chance of developing alcoholic and nonalcoholic fatty liver disease across people of different ancestries.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11138627

Related topics

Quick answers

How many Fatty Liver clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (6 trials), Egypt (3 trials), Spain (1 trial), India (1 trial), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1/2: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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