Hepatitis B and HIV Cure Network to help people with HIV and hepatitis B

Who could benefit from this research

What this research studies

This project builds a large, international group of people living with HIV and chronic hepatitis B to study how a functional cure could be achieved. It uses advanced technologies and a shared clinical repository to analyze samples from diverse genotypes, with liver biopsies and blood draws to track changes over time. The goal is to identify factors linked to sustained HBsAg loss off treatment and to accelerate progress toward a cure that benefits people in the U.S. and around the world. Participation would involve regular follow-up visits and sample collection over several years at multiple sites. The research emphasizes collaboration, rigorous data sharing, and a patient-centered approach to translating findings into future care.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Thio, Chloe L — Johns Hopkins University
• Study coordinator: Thio, Chloe L

Related research

Other NIH-funded projects on the same topics.

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  NIH research Johns Hopkins University · Baltimore, United States · NIH-11600326

• HBV cure factors in people with and without HIV

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• HBV prevention in community pharmacies: a first step in a low-resource setting

  This pilot project tests whether hepatitis B screening and vaccination can be integrated into everyday community pharmacy services to reach more people.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11473743

• Blood markers to catch early liver cancer in Hispanic people with hepatitis B

  This project will see if a blood test can find liver cancer earlier in Hispanic people who have chronic hepatitis B.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11473605

• Early blood markers to find hepatitis B–related liver cancer in Hispanics

  This project will use immune-related blood markers to find liver cancer earlier in people with chronic hepatitis B, focusing on Hispanic adults.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11473604

• HBV safety with long-acting HIV therapy for people with HIV

  A study to understand how long-acting HIV meds affect hepatitis B in people living with HIV and how to best monitor and protect them.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11470595

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.