Understanding how different hepatitis B vaccines affect immune responses in people living with HIV
Dissecting Hepatitis B Vaccine Adjuvant Effects on Immune Responses and the HIV Reservoir in PLWH
This study is looking at how well two different hepatitis B vaccines work for people living with HIV, comparing the usual vaccine, ENGERIX-B, with a newer one, HEPLISAV-B, to see if the new vaccine offers better protection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11144593 on NIH RePORTER |
What this research studies
This research investigates the immune responses generated by two different hepatitis B vaccines in individuals living with HIV. It compares the standard vaccine, ENGERIX-B, with a newer vaccine, HEPLISAV-B, which uses a special adjuvant to enhance the immune response. By analyzing the immune signatures and responses from both vaccines, the study aims to identify why HEPLISAV-B may lead to better protection against hepatitis B in this population. The findings could help improve vaccination strategies for people living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have previously been vaccinated against hepatitis B but did not achieve protective antibody levels.
Not a fit: Patients who are not living with HIV or those who have not been vaccinated against hepatitis B may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective hepatitis B vaccination strategies for people living with HIV, reducing their risk of liver disease and cancer.
How similar studies have performed: Previous research has shown promising results with the HEPLISAV-B vaccine, indicating that this approach could lead to significant advancements in hepatitis B vaccination for people living with HIV.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Cox, Andrea L — Johns Hopkins University
- Study coordinator: Cox, Andrea L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.