Hepatitis B and HIV Cure Consortium: building a global effort to find a functional cure for HBV in people with HIV
Official title: Hepatitis B and HIV Cure Consortium (BICC)
Funded at Johns Hopkins University · NIH-11419732 · Data updated 2026-11-12
A wide, international effort is gathering people with HIV and hepatitis B to study and share samples and data in the search for a functional cure for HBV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 17, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $4,680,912 |
| NIH project number | 5U19AI188551-02 |
| Project ID | NIH-11419732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals living with HIV who also have chronic hepatitis B and are eligible for cohort participation.
✕Less likely to help
People without HIV or chronic hepatitis B, or those who choose not to participate, may not directly benefit.
What this research studies
This project creates a multinational cohort of people living with HIV and chronic hepatitis B to apply new technologies to HBV cure research. It collects clinical data and biological samples from diverse genotypes and follows participants semi-annually, with liver biopsies and blood draws at key time points. The goal is to understand what leads to loss of hepatitis B surface antigen off treatment and to build a repository that supports future research and trials. By including sites in the US and several other countries, the study aims to accelerate discovery that could benefit people with HIV and HBV. Participants can contribute to a global effort that may advance HBV cure strategies.
Why it matters
Potential benefit: If successful, the research could bring us closer to a functional cure for HBV in people living with HIV.
How similar studies have gone: Previous HBV cure research has laid groundwork; this consortium builds a large, diverse cohort and infrastructural resources to accelerate progress.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Thio, Chloe L — Johns Hopkins University
- Study coordinator: Thio, Chloe L
Related research
Other NIH-funded projects on the same topics.
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HBV cure clues in people with and without HIV
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-
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-
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This project will use immune-related blood markers to find liver cancer earlier in people with chronic hepatitis B, focusing on Hispanic adults.
-
HBV safety with long-acting HIV therapy for people with HIV
A study to understand how long-acting HIV meds affect hepatitis B in people living with HIV and how to best monitor and protect them.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.