Personalized dietary responses for better health
Official title: Personalized Responses to Dietary Composition Trial 3
Run by Zoe Global Limited · NCT04735835 · Data updated 2026-11-12
This study is testing how different foods affect people's health based on their unique responses, and it's for individuals taking part in the ZOE testing program.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250000 (estimated) |
| Sponsor | Zoe Global Limited Academic / other |
| Locations | 2 sites (Needham, Massachusetts and 1 other locations) |
| Status | Recruiting |
| Started | July 20, 2020 |
| Main results expected | January 1, 2030 |
| Study ends | January 1, 2030 |
| Registry record updated | April 16, 2025 |
| Trial ID | NCT04735835 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years old who are enrolled in the ZOE testing program and have a BMI of at least 16.5 kg/m2.
✕Probably not a fit
Patients who cannot safely consume the standardized meals due to allergies or other medical conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The PREDICT 3 study aims to enhance precision nutrition by analyzing individual responses to food through machine learning models. Participants, who must be enrolled in the ZOE testing program, will undergo a dietary intervention involving standardized meals and a free-living period to track their dietary habits. The study will assess how various factors like exercise and sleep influence metabolic responses after meals. This research builds on previous findings from over 2,000 individuals and utilizes a commercial product to gather extensive data from participants.
Why it matters
Potential benefit: If successful, this study could lead to personalized dietary recommendations that improve metabolic health for individuals with diabetes and heart diseases.
How similar studies have gone: Previous studies in this area have shown promise in personalizing nutrition based on individual metabolic responses, indicating a potential for success in this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Enrolled in the commercial ZOE testing program * Any sex * Minimum 18 years of age (minimum 19 years of age in Alabama and Nebraska due to state laws) * Body mass index (BMI) of greater than or equal to 16.5 kg/m2. * Living in the continental US states, other than in New York (excluded from the ZOE testing product also as they are unable to access the dried blood spot service provided by Quest), or living in the UK * Able and willing to comply with the study protocol and provide informed consent. * Under care for chronic medical conditions (including eating disorders, type 1 diabetes, type 2 diabetes), and confirm they have checked with their primary care physician that this study is safe for them (US cohort only) Exclusion Criteria: * Cannot safely eat the pre-made test meals which contain standard US ingredients, e.g. due to allergy or recent gastrointestinal surgery, or are unwilling to consume these foods. * Are pregnant. * Have had a heart attack (myocardial infarction), stroke/transient ischemic attack (TIA), or major surgery in the last two months. * Are unable to read and write in English, as the ZOE app is only available in English.
Where it's running
-
Zoe US Inc.
Needham, Massachusetts, United States Recruiting -
King's College London
London, United Kingdom Recruiting
Study contacts
- Principal investigator: Tim Spector, PhD — Zoe Global Limited
- Study coordinator: Meaghan Reardon
- Email: meaghan@joinzoe.com
- Phone: 866-771-7478
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.