Understanding how certain molecules affect recovery after heart surgery in children
Official title: The role of damage-associated molecular patterns in perioperative morbidities and mortalities of pediatric congenital heart diseases
Funded at Boston Children's Hospital · NIH-10669290 · Data updated 2026-11-12
This study is looking at how certain molecules released during heart surgery for kids with congenital heart diseases affect their recovery and overall health, with the goal of finding better ways to help them heal.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $221,250 |
| NIH project number | 5R21HD109119-02 |
| Project ID | NIH-10669290 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are neonates and infants with congenital heart diseases who are scheduled for cardiac surgery.
✕Less likely to help
Patients with congenital heart diseases who are not undergoing surgery or are older than the pediatric age range may not benefit from this research.
What this research studies
This research investigates the role of damage-associated molecular patterns (DAMPs) in the health outcomes of children undergoing cardiac surgery for congenital heart diseases. By analyzing how these molecules are released during tissue injury, the study aims to understand their impact on inflammation and organ function post-surgery. The approach includes measuring DAMP levels in the bloodstream and correlating them with patient outcomes, which could lead to improved clinical strategies and therapies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment strategies that reduce complications and improve recovery for children undergoing heart surgery.
How similar studies have gone: Previous research has shown that understanding DAMPs in other contexts, such as trauma and sepsis, can lead to significant improvements in patient outcomes, suggesting potential for success in this area as well.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Yuki, Koichi — Boston Children's Hospital
- Study coordinator: Yuki, Koichi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.