Using fibrinolysis inhibitors after heart surgery to reduce blood transfusions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of routine extended use of fibrinolysis inhibitors during and after cardiac surgery to reduce the need for postoperative blood transfusions. It is a pragmatic, multi-center, cluster crossover trial that compares a policy of administering these inhibitors both during surgery and for four hours post-transfer to the ICU against a policy that only uses them during surgery. The study aims to address the variability in the use of fibrinolysis inhibitors across clinics and to determine the optimal dosing regimen for better patient outcomes. By investigating the potential benefits of extended administration, the study seeks to provide clearer guidelines for clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. A hospital that performs a minimum of 250 open heart interventions per year.
2. Consent from hospital physicians regarding the prophylactic use of fibrinolysis inhibitors (more than 95% of physicians involved in the treatment of adult patients (\>18 years) agree to adhere to the strategy of using fibrinolysis inhibitors as prescribed by the study protocol).

Exclusion Criteria:

* Hospital does not meet inclusion criteria

Where it's running

• Cardiac surgery department, Saint-Petersburg state university hospital
  Saint Petersburg, Russia Recruiting
• St. Petersburg State University Hospital
  Saint Petersburg, Russia Not yet recruiting

Study contacts

• Study coordinator: Sergey Efremov, PhD
• Email: efremovsergm@gmail.com
• Phone: +79137946090

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.