Comparing heart imaging techniques for coronary artery disease
Myocardial Perfusion Quantification With Single Photon Emission Computed Tomography Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary Computed Tomography Angiography
This study is testing if a new heart imaging method can better identify problems in patients suspected of having coronary artery disease compared to a traditional imaging technique.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Semmelweis University Academic / other |
| Locations | 1 site (Budapest, Budapest) |
| Trial ID | NCT06670768 on ClinicalTrials.gov |
What this trial studies
This prospective study aims to compare the functional abnormalities detected by myocardial perfusion SPECT imaging with the anatomical findings from coronary computed tomography angiography in patients suspected of having coronary artery disease. The study will enroll 50 patients who will undergo both imaging modalities, including pharmacological stress and rest-phase dynamic and static MPI SPECT, followed by coronary CTA. The goal is to enhance the diagnostic value of MPI SPECT by quantifying myocardial blood flow and calculating myocardial flow reserve, ultimately improving risk assessment for patients with moderate cardiovascular risk.
Who should consider this trial
Good fit: Ideal candidates are patients with suspected coronary artery disease who are referred for either coronary CTA or MPI SPECT.
Not a fit: Patients with moderate or severe aortic valve stenosis, atrial fibrillation, or those with a history of coronary artery bypass graft implantation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and risk assessment for patients with coronary artery disease.
How similar studies have performed: Other studies have shown promise in enhancing myocardial perfusion imaging techniques, but this specific approach using multi-pinhole collimator technology is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * suspected coronary artery disease * referred to coronary CTA or SPECT MPI by the patient's physician * agrees to the other imaging modality that was not indicated by their physician (coronary CTA or SPECT MPI) * suitable for informed consent Exclusion Criteria: * moderate or severe aortic valve stenosis * atrial fibrillation * pregnancy or breastfeeding * history of coronary artery bypass graft implantation * history of stent implantation * chronic renal failure (eGFR \< 30 ml/m2) * active oncological treatment * congenital heart disease * left or right bundle branch block
Where this trial is running
Budapest, Budapest
- Semmelweis University, Medical Imaging Centre — Budapest, Budapest, Hungary (Recruiting)
Study contacts
- Principal investigator: Pál Maurovich-Horvat, Prof. Dr. — Semmelweis University Medical Imaging Centre
- Study coordinator: Pál Maurovich-Horvat, Prof. Dr.
- Email: maurovich-horvat.pal@semmelweis.hu
- Phone: +36206632485
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.