How mechanical load affects heart function and diseases
Mechanical Load Effects on Cardiac Function and Heart Diseases
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11045773
This study is looking at how the pressure and strain on heart muscle cells affect their function, which could help us understand and treat heart problems like arrhythmias and heart failure better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11045773 on ClinicalTrials.gov |
What this research studies
This research investigates how mechanical load influences the function of heart muscle cells, known as cardiomyocytes, and its implications for heart diseases like arrhythmias and heart failure. By developing a novel technology to apply mechanical load at the single-cell level, the study aims to uncover the cellular mechanisms that allow cardiomyocytes to adapt to changes in load during each heartbeat. The research will explore the feedback loops involved in the excitation-contraction coupling process, which is crucial for maintaining proper heart function. Ultimately, this work seeks to fill existing knowledge gaps and improve therapeutic strategies for heart conditions related to mechanical stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from heart diseases, particularly those with arrhythmias or heart failure related to mechanical overload.
Not a fit: Patients with non-cardiac related conditions or those without any heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart diseases that arise from mechanical stress, potentially improving outcomes for patients with conditions like heart failure and arrhythmias.
How similar studies have performed: While the approach of studying mechanical load effects on cardiomyocytes is innovative, previous research has shown promise in understanding cellular responses to mechanical stress, indicating potential for success.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN-IZU, YE — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: CHEN-IZU, YE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders