Improving heart disease risk prediction for diverse populations
Official title: Addressing Disparities in Polygenic Risk Score for Coronary Heart Diseases in Diverse Populations
Funded at J. David Gladstone Institutes · NIH-10864740 · Data updated 2026-11-12
This study is working to create better tools for predicting the risk of heart disease by looking at both your genes and other health factors, especially for people from different backgrounds, so that everyone can get fairer and more accurate health care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $179,280 |
| NIH project number | 1K01HL173644-01 |
| Project ID | NIH-10864740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse ancestral backgrounds, particularly those at risk for coronary heart disease.
✕Less likely to help
Patients with coronary heart disease who do not belong to diverse ancestral backgrounds may not receive direct benefits from this research.
What this research studies
This research aims to enhance the prediction of coronary heart disease (CHD) risk by developing polygenic risk scores (PRS) that are more accurate for individuals from diverse ancestries. The approach combines genetic data with traditional clinical risk factors while also considering social and environmental influences that contribute to health disparities. By analyzing genetic information from various populations, the study seeks to identify low-frequency genetic variants and improve the representation of diverse genetic backgrounds in risk assessments. This tailored strategy aims to provide more equitable healthcare outcomes for all individuals, particularly those from underrepresented groups.
Why it matters
Potential benefit: If successful, this research could lead to more accurate heart disease risk assessments, enabling earlier and more effective interventions for diverse populations.
How similar studies have gone: Other research has shown promise in improving risk prediction models by incorporating diverse genetic data, suggesting that this approach could yield significant advancements.
Where this research is happening
-
J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Tcheandjieu, Catherine — J. David Gladstone Institutes
- Study coordinator: Tcheandjieu, Catherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.