Investigating how WNT4 affects gynecologic cancer disparities
Elucidating a novel WNT4 regulatory axis as a driver of gynecologic cancer health disparities
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-10932972
This study is looking at how a gene called WNT4 might affect ovarian cancer in women, especially how it could influence cancer growth and treatment responses, with the hope of finding better ways to help patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10932972 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the WNT4 gene in gynecologic cancers, particularly ovarian cancer, which is known for its high mortality rates among women. The study examines how specific genetic variations in WNT4 may contribute to cancer growth, therapy resistance, and disparities in health outcomes. By utilizing advanced techniques like CRISPR, researchers aim to uncover the mechanisms by which WNT4 influences cancer cell behavior and patient responses to treatment. This could lead to better-targeted therapies and improved patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research include women diagnosed with ovarian cancer, especially those with known genetic variations in the WNT4 gene.
Not a fit: Patients with non-gynecologic cancers or those without any genetic predisposition related to WNT4 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for ovarian cancer, particularly for those patients who are currently resistant to standard therapies.
How similar studies have performed: Previous studies have shown promising results linking WNT4 genetic variations to cancer risk, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIKORA, MATTHEW J — UNIVERSITY OF COLORADO DENVER
- Study coordinator: SIKORA, MATTHEW J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.