Using 3D Ultrasound for Needle Guidance in Gynecological Cancer Treatment
Official title: A Multi-Modality Comparison of Needle Placement During Gynecological Brachytherapy Procedures
Run by Western University, Canada · NCT04705467 · Data updated 2026-11-12
This study is testing if using 3D ultrasound can help doctors place needles more accurately during radiation treatment for women with gynecological cancers.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 35 (estimated) |
| Sponsor | Western University, Canada Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (London, Ontario) |
| Status | Recruiting |
| Started | October 15, 2022 |
| Main results expected | October 2025 |
| Study ends | June 2026 |
| Registry record updated | April 13, 2025 |
| Trial ID | NCT04705467 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include females aged 18 and older with locally advanced or recurrent gynecological cancers who are eligible for interstitial or ring and tandem brachytherapy.
✕Probably not a fit
Patients who are not offered interstitial brachytherapy as a treatment option will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study explores the use of 3D ultrasound imaging to guide needle insertion during brachytherapy for gynecological cancers. Brachytherapy is a critical treatment that delivers radiation directly to tumors while minimizing damage to surrounding healthy tissue. The study aims to improve the precision of needle placement in the pelvis, which is currently guided by clinical examination and pre-treatment imaging without standardized methods. By providing real-time imaging, the goal is to enhance treatment outcomes for patients with advanced or recurrent gynecological malignancies.
Why it matters
Potential benefit: If successful, this approach could lead to more effective brachytherapy treatments with reduced side effects for patients.
How similar studies have gone: While the use of imaging in brachytherapy is established, the specific application of 3D ultrasound for needle guidance in this context is relatively novel and has not been widely tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Females of age eighteen (18) or greater. * Patients with locally advanced or recurrent gynecological malignancies who are offered interstitial or ring and tandem brachytherapy treatment. These typically would include patients with primary or recurrent vaginal cancers, endometrial cancers or cervical cancers. Histologies of these cancers are typically adenocarcinomas or squamous cell carcinomas Exclusion Criteria: • Above patients who are not offered interstitial brachytherapy as a treatment modality
Where it's running
-
London Regional Cancer Program, Victoria Hospital
London, Ontario, Canada Recruiting
Study contacts
- Study coordinator: David D'Souza, MD
- Email: David.DSouza@lhsc.on.ca
- Phone: 519-685-8500
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.