3D printed applicators for treating gynecologic cancers
Study of 3D-printed Custom Applicators for Intracavitary HDR Gynaecological Brachytherapy (DISCO)
This study is testing whether 3D-printed custom applicators can make radiation treatment more effective for patients with gynecologic cancers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Royal North Shore Hospital Academic / other |
| Locations | 1 site (St Leonards, New South Wales) |
| Trial ID | NCT06432478 on ClinicalTrials.gov |
What this trial studies
This study investigates the feasibility of using 3D-printed custom applicators for intracavitary brachytherapy in patients with gynecologic cancers. Traditional applicators can be complex and time-consuming to create, often leading to devices that do not meet design specifications. In contrast, 3D printing allows for the production of patient-specific applicators that are more efficient and cost-effective. The trial aims to assess the effectiveness of these custom applicators in delivering targeted radiation therapy to improve treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates include patients with FIGO stage I-IVA gynecologic cancers who are indicated for intracavitary brachytherapy.
Not a fit: Patients who are pregnant or have contraindications for brachytherapy will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the precision and effectiveness of brachytherapy for patients with gynecologic cancers.
How similar studies have performed: While the use of 3D printing in medical applications is gaining traction, this specific approach for brachytherapy in gynecologic cancers is novel and has not been widely tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to give informed consent * Patients indicated for intracavitary brachytherapy * FIGO stage I-IVA * ECOG 0-2 * Primary endometrial cancer, primary vaginal cancer, primary vulva cancer, recurrent gynaecological cancer Exclusion Criteria: * Pregnancy * Patients contraindicated for brachytherapy * Inflammatory bowel disease/history of adhesions/bowel obstruction * Renal transplant/horseshoe kidney * Patients with significant LVSI or pelvic sidewall invasion * Patients requiring interstitial brachytherapy implants
Where this trial is running
St Leonards, New South Wales
- Royal North Shore Hospital — St Leonards, New South Wales, Australia (Recruiting)
Study contacts
- Principal investigator: Marita Morgia, MD — Royal North Shore Hospital
- Study coordinator: Marita Morgia, MD
- Email: Marita.Morgia@health.nsw.gov.au
- Phone: 9463 1300
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.