Using a smartphone brain-training app to reduce chemo‑brain in gynecologic cancer patients
Official title: Using a Novel Mobile Cognitive Training Application to Improve Cancer-related Cognitive Impairment in Gynecologic Oncology Patients
Run by University of Alabama at Birmingham · NCT05864274 · Data updated 2026-11-12
This will test whether a mobile cognitive training app can reduce chemo‑brain symptoms in people with gynecologic cancers who are receiving chemotherapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | Women only |
| Enrollment | 64 (estimated) |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Birmingham, Alabama) |
| Status | Recruiting |
| Started | September 1, 2024 |
| Main results expected | August 1, 2027 |
| Study ends | August 1, 2027 |
| Registry record updated | November 24, 2025 |
| Trial ID | NCT05864274 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 21 with a newly diagnosed gynecologic malignancy who are starting chemotherapy, own a smartphone or tablet, and do not have dementia or unstable psychiatric illness on multiple medications.
✕Probably not a fit
Patients with a medical diagnosis of dementia, those on multiple psychiatric medications for severe mental illness, individuals without a compatible smartphone/tablet, or those not receiving chemotherapy are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients newly diagnosed with gynecologic malignancies who are starting chemotherapy will be enrolled at the University of Alabama at Birmingham and asked to use a cognitive training application on their smartphone or tablet. Neurocognitive baseline testing and follow-up assessments will be performed by a multidisciplinary neurocognitive team to track changes in memory, processing speed, and executive function. Participation requires ownership of a compatible device and in-person visits for assessments at the Birmingham site. The intervention is a structured mobile cognitive training program delivered alongside usual oncologic care.
Why it matters
Potential benefit: If successful, the app could reduce memory and thinking problems from chemotherapy and improve daily functioning and quality of life.
How similar studies have gone: Some cognitive training interventions have shown modest benefits for chemotherapy-related cognitive symptoms in other cancer groups such as breast cancer, but targeted data in gynecologic oncology are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria are: * newly diagnosed gynecologic malignancy (uterine, cervical, ovarian, primary peritoneal, vulvar, or vaginal) and undergoing chemotherapy * own a smartphone or tablet with ability to download cognitive training application * and age \>21 years old Exclusion criteria include: * medical diagnosis of dementia * significant underlying mental diagnoses for which they are on more than 1 medication for (patients with depression or anxiety on single-agent therapy will be able to participate * age \<21
Where it's running
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University of Alabama at Birmingham
Birmingham, Alabama, United States Recruiting
Study contacts
- Study coordinator: Teresa K Boitano, MD
- Email: tlboitano@uabmc.edu
- Phone: 2059344986
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.