Clinical trial Recruiting at 1 site Interventional Ages 18 to 90 Women only

Using a smartphone brain-training app to reduce chemo‑brain in gynecologic cancer patients

Official title: Using a Novel Mobile Cognitive Training Application to Improve Cancer-related Cognitive Impairment in Gynecologic Oncology Patients

Run by University of Alabama at Birmingham · NCT05864274 · Data updated 2026-11-12

This will test whether a mobile cognitive training app can reduce chemo‑brain symptoms in people with gynecologic cancers who are receiving chemotherapy.

More Gynecologic Cancer trials

Quick facts

Study typeInterventional
Ages18 Years to 90 Years
SexWomen only
Enrollment64 (estimated)
SponsorUniversity of Alabama at Birmingham
Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Birmingham, Alabama)
StatusRecruiting
StartedSeptember 1, 2024
Main results expectedAugust 1, 2027
Study endsAugust 1, 2027
Registry record updatedNovember 24, 2025
Trial IDNCT05864274 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults over 21 with a newly diagnosed gynecologic malignancy who are starting chemotherapy, own a smartphone or tablet, and do not have dementia or unstable psychiatric illness on multiple medications.

Probably not a fit

Patients with a medical diagnosis of dementia, those on multiple psychiatric medications for severe mental illness, individuals without a compatible smartphone/tablet, or those not receiving chemotherapy are unlikely to benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients newly diagnosed with gynecologic malignancies who are starting chemotherapy will be enrolled at the University of Alabama at Birmingham and asked to use a cognitive training application on their smartphone or tablet. Neurocognitive baseline testing and follow-up assessments will be performed by a multidisciplinary neurocognitive team to track changes in memory, processing speed, and executive function. Participation requires ownership of a compatible device and in-person visits for assessments at the Birmingham site. The intervention is a structured mobile cognitive training program delivered alongside usual oncologic care.

Why it matters

Potential benefit: If successful, the app could reduce memory and thinking problems from chemotherapy and improve daily functioning and quality of life.

How similar studies have gone: Some cognitive training interventions have shown modest benefits for chemotherapy-related cognitive symptoms in other cancer groups such as breast cancer, but targeted data in gynecologic oncology are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion criteria are:

* newly diagnosed gynecologic malignancy (uterine, cervical, ovarian, primary peritoneal, vulvar, or vaginal) and undergoing chemotherapy
* own a smartphone or tablet with ability to download cognitive training application
* and age \>21 years old

Exclusion criteria include:

* medical diagnosis of dementia
* significant underlying mental diagnoses for which they are on more than 1 medication for (patients with depression or anxiety on single-agent therapy will be able to participate
* age \<21

Where it's running

  • University of Alabama at Birmingham
    Birmingham, Alabama, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.