Using a smartphone brain-training app to reduce chemo‑brain in gynecologic cancer patients
Using a Novel Mobile Cognitive Training Application to Improve Cancer-related Cognitive Impairment in Gynecologic Oncology Patients
This will test whether a mobile cognitive training app can reduce chemo‑brain symptoms in people with gynecologic cancers who are receiving chemotherapy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 64 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | Female |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Birmingham, Alabama) |
| Trial ID | NCT05864274 on ClinicalTrials.gov |
What this trial studies
Patients newly diagnosed with gynecologic malignancies who are starting chemotherapy will be enrolled at the University of Alabama at Birmingham and asked to use a cognitive training application on their smartphone or tablet. Neurocognitive baseline testing and follow-up assessments will be performed by a multidisciplinary neurocognitive team to track changes in memory, processing speed, and executive function. Participation requires ownership of a compatible device and in-person visits for assessments at the Birmingham site. The intervention is a structured mobile cognitive training program delivered alongside usual oncologic care.
Who should consider this trial
Good fit: Ideal candidates are adults over 21 with a newly diagnosed gynecologic malignancy who are starting chemotherapy, own a smartphone or tablet, and do not have dementia or unstable psychiatric illness on multiple medications.
Not a fit: Patients with a medical diagnosis of dementia, those on multiple psychiatric medications for severe mental illness, individuals without a compatible smartphone/tablet, or those not receiving chemotherapy are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, the app could reduce memory and thinking problems from chemotherapy and improve daily functioning and quality of life.
How similar studies have performed: Some cognitive training interventions have shown modest benefits for chemotherapy-related cognitive symptoms in other cancer groups such as breast cancer, but targeted data in gynecologic oncology are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria are: * newly diagnosed gynecologic malignancy (uterine, cervical, ovarian, primary peritoneal, vulvar, or vaginal) and undergoing chemotherapy * own a smartphone or tablet with ability to download cognitive training application * and age \>21 years old Exclusion criteria include: * medical diagnosis of dementia * significant underlying mental diagnoses for which they are on more than 1 medication for (patients with depression or anxiety on single-agent therapy will be able to participate * age \<21
Where this trial is running
Birmingham, Alabama
- University of Alabama at Birmingham — Birmingham, Alabama, United States (Recruiting)
Study contacts
- Study coordinator: Teresa K Boitano, MD
- Email: tlboitano@uabmc.edu
- Phone: 2059344986
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.