Targeting harmful p53 mutations in gynecologic cancers
Official title: Attacking aggressive p53 mutants in gynecologic cancer
Funded at University of Iowa · NIH-10894679 · Data updated 2026-11-12
This study is looking at new, personalized treatments for ovarian and endometrial cancers linked to changes in the p53 gene, using cutting-edge techniques to help create options that work better for patients based on their specific tumor characteristics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $186,840 |
| NIH project number | 5K22CA263783-03 |
| Project ID | NIH-10894679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with ovarian or endometrial cancer who have p53 mutations.
✕Less likely to help
Patients without p53 mutations or those with other types of gynecologic cancers may not benefit from this research.
What this research studies
This research focuses on developing personalized RNA-based therapies to treat ovarian and endometrial cancers caused by specific mutations in the p53 gene. By understanding how these mutations alter the function of the p53 protein, the research aims to create targeted treatments that can effectively counteract the negative effects of these mutations. The approach involves using advanced techniques like CRISPR to manipulate genetic material and assess the impact on cancer cells. Patients may benefit from more effective and tailored treatment options that address the unique characteristics of their tumors.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for women with aggressive gynecologic cancers.
How similar studies have gone: Previous research has shown promise in targeting p53 mutations with novel therapeutic approaches, indicating potential for success in this area.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Thiel, Kristina W — University of Iowa
- Study coordinator: Thiel, Kristina W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.