Understanding frailty in gynecologic cancer patients to improve recovery
Official title: PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery - PROOF Prospective Cohort Study
Run by University of California, San Francisco · NCT06089083 · Data updated 2026-11-12
This study looks at how frailty affects recovery and quality of life in adults newly diagnosed with gynecologic cancer to see what factors might contribute to being frail.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 500 (estimated) |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 2 sites (San Francisco, California and 1 other locations) |
| Status | Recruiting |
| Started | October 18, 2023 |
| Main results expected | November 30, 2027 |
| Study ends | November 30, 2033 |
| Registry record updated | January 26, 2026 |
| Trial ID | NCT06089083 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are undergoing evaluation for a newly diagnosed gynecologic malignancy.
✕Probably not a fit
Patients who are unable to provide informed consent or have contraindications to study-related procedures may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the impact of frailty on the outcomes and quality of life in adult patients newly diagnosed with gynecologic cancer. The primary objective is to identify risk factors associated with frailty in these patients. Secondary objectives include comparing the quality of life, specifically 'healthy days at home,' between frail and non-frail participants, as well as evaluating other perioperative and oncologic outcomes. Participants will be recruited at the time of diagnosis and followed for up to one year post-surgery.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery strategies for frail gynecologic cancer patients, enhancing their quality of life.
How similar studies have gone: Other studies have explored frailty in cancer patients, indicating potential for meaningful insights, though this specific approach may be novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or greater * Undergoing evaluation for a newly diagnosed gynecologic malignancy * Ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it Exclusion Criteria: * Contraindication to any study-related procedure or assessment * Does not speak a language for which the consent form and study materials are available
Where it's running
-
University of California, San Francisco
San Francisco, California, United States Recruiting -
Dana Farber Cancer Institute
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Stephanie Cham, MD — University of California, San Francisco
- Study coordinator: Janet Titzler
- Email: janet.titzler@ucsf.edu
- Phone: 415-353-9600
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
NMTCuff vs standard TOF monitoring during gynecologic oncology surgery
This study tests whether NMTCuff monitoring can better detect neuromuscular recovery than standard TOF monitoring in women undergoing laparoscopic gynecologic cancer surgery.
-
Radiotherapy for gynecologic cancer with up to 10 metastatic sites
This registry follows adults with gynecologic cancer who have 1 to 10 active metastatic lesions and are treated with radiotherapy as part of routine care to see how such treatments work in real-world settings.
-
Personalized supervised exercise program for adults with breast or gynecologic cancer
A small pilot study will test a supervised, personalized exercise program to see if it is safe, feasible, and acceptable for adults with a history of breast or gynecologic cancer.
-
Blended e-Health Program to Help Women with Breast or Gynecologic Cancer Manage Fear of Cancer Progression
This trial tests a blended online and group program to see if it helps women with breast or gynecologic cancer feel less fear that their cancer could grow or spread.
-
Feasibility of using SmartMatch for guiding treatment options in rare gynecologic cancers
This observational study tests whether SmartMatch analysis on tissue from standard surgeries or biopsies can help identify treatment options for adults with advanced rare gynecologic cancers.
-
Cesium-131 brachytherapy to preserve organs in recurrent cervical or endometrial cancer
This study tests whether implanting small cesium-131 seeds can provide targeted radiation to vaginal recurrences of cervical or endometrial cancer in patients who previously had pelvic radiation, with the goal of preserving organs.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.