Investigating how STAG2 mutations affect genome organization in brain tumors.
Official title: STAG2 mutations and 3D genome organization in glioblastoma multiforme
Funded at Georgetown University · NIH-10911159 · Data updated 2026-11-12
This study is looking at how changes in a specific gene called STAG2 might affect the way brain tumor cells are organized and behave, which could help us understand more about glioblastoma and how it grows.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 10, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $508,673 |
| NIH project number | 5R01CA267872-03 |
| Project ID | NIH-10911159 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma multiforme, particularly those with STAG2 mutations.
✕Less likely to help
Patients with other types of brain tumors or those without STAG2 mutations may not benefit from this research.
What this research studies
This research focuses on glioblastoma multiforme, the most common primary brain tumor, and examines the role of STAG2 mutations in altering the 3D organization of the genome. By utilizing advanced gene editing techniques, the researchers aim to understand how these mutations impact gene expression and contribute to tumor development. The study employs innovative bioinformatics tools to analyze chromatin loops and transcriptional changes in brain tumor cells, providing insights into the underlying mechanisms of cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting the genetic and epigenetic alterations in glioblastoma.
How similar studies have gone: Other research has shown promising results in understanding the role of chromatin organization in cancer, making this approach both relevant and potentially impactful.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Waldman, Todd a — Georgetown University
- Study coordinator: Waldman, Todd a
Related research
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STAG2 mutations and 3D genome organization in glioblastoma
A study in adults with glioblastoma examines how STAG2 gene mutations may change the 3D structure of DNA in tumor cells and drive cancer.
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Understanding the STAG2 Gene in Brain Tumors
This project aims to understand how changes in a specific gene called STAG2 contribute to the growth of glioblastoma, a common type of brain tumor.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.