Condition

Glioblastoma, IDH-wildtype clinical trials and research

• 25Clinical trials
• 14Countries

Newest Glioblastoma, IDH-wildtype clinical trials

All recruiting trials (25)

• Temozolomide with or without WSD0922-FU for EGFR-Mutant, IDH-Wildtype Glioblastoma

  This trial tests whether adding WSD0922-FU to temozolomide helps slow disease progression in adults with EGFR-mutant, IDH-wildtype glioblastoma.

  Recruiting at 3 sites Phase 2 Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT07708961

• Retifanlimab With or Without DFMO for Progressive High-Grade Gliomas

  This trial tests whether retifanlimab, with or without DFMO, is safe and may help treat progressive high-grade gliomas in adults.

  Recruiting Phase 1/2 Mayo Clinic · Rochester, Minnesota · NCT07468136

• Temporally-Modulated Pulsed Radiation Therapy plus TMZ for MGMT-Unmethylated Glioblastoma

  This study tests whether temporally-modulated pulsed radiation therapy plus temozolomide improves outcomes for people with newly diagnosed MGMT-unmethylated, IDH-wildtype glioblastoma.

  Recruiting at 54 sites Phase 3 NRG Oncology · Irvine, California and 53 other locations · NCT07452458

• GI-102 With or Without Pembrolizumab Before Surgery for Recurrent or Progressive Grade 4 Gliomas

  The team will test whether giving GI-102 alone or together with pembrolizumab before surgery helps adults with recurrent or progressive IDH‑wildtype glioblastoma or IDH‑mutant grade 4 astrocytoma.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07301268

• 177Lu-PSMA-617 treatment for IDH‑wildtype gliomas

  This trial will test whether the radiopharmaceutical 177Lu-PSMA-617 is safe for adults with IDH‑wildtype gliomas who have completed standard surgery and radiation.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07223034

• Using a continuous glucose monitor to manage high blood sugar in glioblastoma

  We will try continuous glucose monitors to help adults with newly diagnosed glioblastoma control high blood sugar during treatment.

  Recruiting Mayo Clinic · Phoenix, Arizona and 2 other locations · NCT07091864

• ERAS-801 for operable or recurrent EGFR-altered IDH-wildtype Grade IV glioblastoma or astrocytoma

  This trial tests ERAS-801, a brain-penetrant EGFR blocker, to see if it is safe and changes tumor metabolism in adults with resectable or recurrent IDH-wildtype Grade IV glioblastoma or astrocytoma that have EGFR amplification or mutation.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California and 1 other locations · NCT07089641

• Adding lomustine to standard care for MGMT‑methylated glioblastoma

  This trial tests whether giving lomustine together with temozolomide and radiation helps adults with newly diagnosed, MGMT‑methylated, IDH‑wildtype glioblastoma live longer.

  Recruiting at 12 sites Phase 3 Vastra Gotaland Region · Graz and 19 other locations · NCT06419946

• Neoadjuvant radiochemotherapy for glioblastoma treatment

  This study is testing a new combination of radiation and chemotherapy before surgery to see if it helps people with glioblastoma feel better and live longer compared to standard treatment.

  Recruiting Phase 1 Hospital San Carlos, Madrid · Madrid · NCT06418113

• Combining Atorvastatin with Temozolomide for Glioblastoma Treatment

  This study is testing if combining a cholesterol-lowering drug called atorvastatin with a cancer medication called temozolomide can help people with a tough type of brain tumor called glioblastoma feel better and live longer.

  Recruiting Phase 2 Tianjin Medical University General Hospital · Tianjin · NCT06327451

• Improving predictions for brain cancer progression using advanced imaging techniques

  This study is testing whether new imaging techniques can help doctors better understand how glioblastoma tumors are behaving and improve treatment for patients who have just been diagnosed.

  Recruiting at 16 sites Phase 2 Eastern Cooperative Oncology Group · Birmingham, Alabama and 17 other locations · NCT06319027

• Comparing surgery and best treatment for recurrent glioblastoma

  This study is testing whether surgery or the best available treatment helps people with recurring glioblastoma feel better and live longer.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06283927

• Resection techniques for recurrent glioblastoma

  This study is testing different methods of mapping the brain during surgery for recurring glioblastoma to see which one helps patients keep their movement and speech abilities while removing as much of the tumor as possible.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06273176

• Analyzing long-term survivors of aggressive solid tumors

  This study looks at patients who have survived much longer than expected from aggressive solid tumors to see what makes them different and if it can help develop new treatments.

  Recruiting Cure 51 · Villejuif · NCT06160596

• Comparing palliative care and surgery for high-grade glioma patients

  This study is testing whether palliative care or surgery helps people with high-grade glioma live longer and feel better.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146738

• Comparing tumor resection and biopsy for high-grade glioma patients

  This study is testing whether removing a brain tumor or just taking a small sample helps older patients with high-grade gliomas live longer and feel better afterward.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146725

• Comparing two surgical approaches for high-grade glioma patients

  This study is testing whether a more extensive surgical method for removing high-grade brain tumors helps patients live longer and feel better compared to a standard approach.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06118723

• Testing NEO212 for treating certain brain tumors and metastases

  This study is testing a new treatment called NEO212 for people with certain types of brain tumors to see if it is safe and effective when combined with standard treatments.

  Recruiting at 8 sites Phase 1/2 Neonc Technologies, Inc. · Beverly Hills, California and 7 other locations · NCT06047379

• Analyzing stem cells and using AI to improve glioblastoma treatment

  This study is testing how stem cells and artificial intelligence can help improve treatment for people with glioblastoma by finding ways to predict their outcomes and making sure patients have the information they need to make informed choices.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT05941234

• Metformin added to temozolomide for newly diagnosed IDH-wildtype glioblastoma

  This Phase 2 trial will test if adding metformin to standard temozolomide helps adults with newly diagnosed IDH-wildtype glioblastoma.

  Recruiting Phase 2 University of Milano Bicocca · Milan · NCT05929495

• Combining eflornithine and temozolomide for newly diagnosed glioblastoma

  This study is testing a new combination of two medications, eflornithine and temozolomide, to find the best dose for people with newly diagnosed glioblastoma.

  Recruiting at 7 sites Phase 1 Orbus Therapeutics, Inc. · Birmingham, Alabama and 7 other locations · NCT05879367

• Combining WP1066 with radiation therapy for newly diagnosed glioblastoma

  This study is testing if adding a new drug called WP1066 to regular radiation therapy can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois and 1 other locations · NCT05879250

• Examining gut microbiome effects in glioblastoma patients undergoing treatment

  This study is trying to see if changes in gut bacteria can affect how well treatment works for adults with newly diagnosed glioblastoma who are getting chemotherapy and radiation.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05326334

• Infusion of Bevacizumab with Chemotherapy and Radiation for Newly Diagnosed Glioblastoma

  This study is testing if adding a special infusion of Bevacizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Northwell Health · New York, New York · NCT05271240

• Using Metformin with Radiotherapy and Temozolomide for Glioblastoma Treatment

  This study is testing if adding metformin to standard treatments of radiotherapy and temozolomide can help people with a specific type of newly diagnosed glioblastoma grow their tumors slower.

  Recruiting at 5 sites Phase 2 Hopital Foch · Suresnes, Hauts de Seine and 6 other locations · NCT04945148

Related topics

Quick answers

How many Glioblastoma, IDH-wildtype clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (17 trials), Belgium (5 trials), Germany (5 trials), Netherlands (5 trials), Switzerland (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1: 4, Phase 3: 3, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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