Understanding the STAG2 Gene in Brain Tumors
Official title: STAG2 mutations and 3D genome organization in glioblastoma multiforme
Funded at Georgetown University · NIH-11146340 · Data updated 2026-11-12
This project aims to understand how changes in a specific gene called STAG2 contribute to the growth of glioblastoma, a common type of brain tumor.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 10, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $535,445 |
| NIH project number | 5R01CA267872-04 |
| Project ID | NIH-11146340 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with glioblastoma whose tumors have STAG2 mutations might eventually benefit from treatments developed based on this fundamental understanding.
✕Less likely to help
Patients with glioblastoma whose tumors do not have STAG2 mutations may not directly benefit from therapies specifically targeting this pathway.
What this research studies
Glioblastoma is a serious brain tumor, and researchers are looking at how changes in our genes might cause it. This project focuses on a gene called STAG2, which is part of a larger complex that helps organize our DNA inside cells. When STAG2 is faulty, it might change how the DNA is structured, potentially leading to tumor growth. By studying these changes in glioblastoma cells, scientists hope to uncover new ways the disease develops.
Why it matters
Potential benefit: If successful, this work could reveal new targets for developing treatments that specifically address the genetic changes driving glioblastoma.
How similar studies have gone: This project builds on recent discoveries about how DNA is organized and uses new computational tools to explore a novel hypothesis about STAG2's role in glioblastoma.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Waldman, Todd a — Georgetown University
- Study coordinator: Waldman, Todd a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.