Understanding the STAG2 Gene in Brain Tumors
STAG2 mutations and 3D genome organization in glioblastoma multiforme
['FUNDING_R01'] · GEORGETOWN UNIVERSITY · NIH-11146340
This project aims to understand how changes in a specific gene called STAG2 contribute to the growth of glioblastoma, a common type of brain tumor.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11146340 on ClinicalTrials.gov |
What this research studies
Glioblastoma is a serious brain tumor, and researchers are looking at how changes in our genes might cause it. This project focuses on a gene called STAG2, which is part of a larger complex that helps organize our DNA inside cells. When STAG2 is faulty, it might change how the DNA is structured, potentially leading to tumor growth. By studying these changes in glioblastoma cells, scientists hope to uncover new ways the disease develops.
Who could benefit from this research
Good fit: Patients with glioblastoma whose tumors have STAG2 mutations might eventually benefit from treatments developed based on this fundamental understanding.
Not a fit: Patients with glioblastoma whose tumors do not have STAG2 mutations may not directly benefit from therapies specifically targeting this pathway.
Why it matters
Potential benefit: If successful, this work could reveal new targets for developing treatments that specifically address the genetic changes driving glioblastoma.
How similar studies have performed: This project builds on recent discoveries about how DNA is organized and uses new computational tools to explore a novel hypothesis about STAG2's role in glioblastoma.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALDMAN, TODD A — GEORGETOWN UNIVERSITY
- Study coordinator: WALDMAN, TODD A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bladder Cancer, Cancer Biology, Cancer Suppressor Genes