Investigating Dichloroacetate for treating aggressive brain tumors
Phase IIA Trial of Dichloroacetate for Glioblastoma Multiforme, IND137007, 09172019
This study is looking at how well a treatment called dichloroacetate (DCA) works for people with glioblastoma, a tough type of brain tumor, to see if it can help improve their health and survival.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10919168 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma multiforme (GBM), a highly aggressive brain tumor with limited treatment options. The study aims to evaluate the effectiveness of dichloroacetate (DCA), a compound that can inhibit certain enzymes involved in tumor metabolism, potentially improving patient outcomes. By targeting the metabolic processes of GBM, the research seeks to provide a new therapeutic approach that could enhance survival rates. Patients will be monitored for safety and efficacy as they receive DCA treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma multiforme who have undergone standard treatment but are facing tumor recurrence.
Not a fit: Patients with other types of brain tumors or those who have not been diagnosed with glioblastoma multiforme may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option that improves survival rates for patients with glioblastoma.
How similar studies have performed: While the use of dichloroacetate in treating glioblastoma is a novel approach, similar metabolic therapies have shown promise in other cancer types.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Stacpoole, Peter Wallace — University of Florida
- Study coordinator: Stacpoole, Peter Wallace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.