MRI-based imaging to guide radiotherapy for glioblastoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses oxygen-enhanced and BOLD MRI to identify hypoxic regions in glioblastoma before and during radiotherapy planning. The goal is to see if MRI-detected hypoxia can guide selective dose escalation to aggressive tumor subregions. Researchers aim to enable personalized radiotherapy and potentially improve local tumor control without extra burdens on patients’ imaging sessions. The study also considers how hypoxia imaging could aid surgical planning and follow-up by identifying resistant or progressing tumor areas. Availability of accelerated MRI sequences could allow hypoxia quantification without relying on less accessible PET imaging.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Suspected high-grade glioma (HGG) / glioblastoma multiforme (WHO grade IV) at initial radiological examination
* Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2
* Available for scanning on two separate days

Exclusion Criteria:

* Women lactating, pregnant or of childbearing potential who are not willing to avoid pregnancy during the study
* Patients with a history of severe renal disease(s) (eGFR \<20) that cannot tolerate gadolinium chelate contrast agents.
* Geographically remote patients unable to agree to imaging schedule
* Patients who have received anti - vascular endothelial growth factor (anti-VEGF) monoclonal antibody therapy the 3 months prior to recruitment
* Patients with a history of psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study.
* Patients with significant cardiac or pulmonary disease including cardiac arrythmias or Chronic Obstructive Pulmonary Disease (COPD) that are unable to tolerate high flow O2 for oxygen contrast.
* Patients taking carbonic anhydrase inhibitors (Acetazolamide)
* History of glaucoma
* Any implant, foreign body, 3 Tesla (3T) MRI incompatible device, or other contraindication to MRI imaging.

Where it's running

• Royal North Shore Hospital
  St Leonards, New South Wales, Australia Recruiting
• North Shore Private Hospital
  St Leonards, New South Wales, Australia Not yet recruiting

Study contacts

• Principal investigator: Caterina Brighi — University of Sydney
• Study coordinator: Shona Silvester
• Email: shona.silvester@sydney.edu.au
• Phone: +61286271185

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.