Condition

E-cigarette Use clinical trials and research

• 14Clinical trials
• 22NIH research projects
• 3New in 30 days
• 4Countries

Newest E-cigarette Use clinical trials

All recruiting trials (14)

• Smoky Futures: Danish Adolescent Nicotine Use over Time

  This observational cohort follows Danish youths ages 15–25 to see how cigarette, e-cigarette, and other nicotine use begin, change, and affect health and education over several years.

  Recruiting University of Southern Denmark · Copenhagen · NCT07910331

• Circuit breathing for quitting e-cigarettes among youth

  A small study tests whether a circuit breathing routine helps young e-cigarette users reduce withdrawal symptoms and improve breathing-related measures.

  Recruiting Chulalongkorn University · Bangkok, Bangkok · NCT07886099

• Behavioral Circuit Breathing Training for Smoking Cessation in Youth Who Use E-cigarettes

  A six-week circuit breathing training program is tested to see if it helps teens and young adults quit e-cigarettes and improve breathing compared with diaphragmatic breathing or usual activities.

  Recruiting Chulalongkorn University · Bangkok, Bangkok · NCT07882407

• Sex differences in how menthol e-cigarettes appeal to people who smoke

  This study tests whether men and women differ in how menthol e-cigarettes with or without nicotine appeal to smokers who have used e-cigarettes before.

  Recruiting Yale University · New Haven, Connecticut · NCT07398976

• Parents Helping Parents for Youth Vaping Cessation

  This project tests whether a parent-supported program can help teens quit vaping by pairing trained parent coaches with families.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT07207850

• How a very-low-nicotine cigarette standard and product prices affect illegal cigarette buying

  This study will test whether requiring very-low-nicotine cigarettes and changing e-cigarette or illegal cigarette prices changes illegal cigarette buying and use of alternatives among adult smokers and dual users.

  Recruiting Virginia Polytechnic Institute and State University · Roanoke, Virginia · NCT07161050

• Varenicline to help adults stop vaping

  This trial tests whether the smoking-cessation pill varenicline helps adults who vape daily quit e-cigarettes.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT07040566

• Culturally Grounded ENDS Prevention for Rural Hawaiian Youth

  This project tests a culturally grounded ENDS prevention program for middle school students on Hawaiʻi Island to see if it helps reduce vaping and related substance use.

  Recruiting University of Hawaii · Honolulu, Hawaii · NCT06929520

• Evaluating e-cigarettes and nicotine pouches for smokers

  This study is testing whether e-cigarettes or nicotine pouches can help long-term smokers quit regular cigarettes and reduce their smoking habits over six weeks.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06372899

• Adapting a counseling program to help young veterans quit vaping

  This study is trying to see if a new counseling program delivered through video calls and phone calls can help young veterans quit vaping better than a self-help guide.

  Recruiting Veterans Medical Research Foundation · San Diego, California · NCT06196489

• Examining how e-cigarette use affects blood vessels differently in men and women

  This study is testing how using e-cigarettes affects blood vessels in young men and women to see if there are any differences in their responses.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT06159608

• Evaluating withdrawal symptoms in e-cigarette users

  This study is testing how withdrawal symptoms affect people who only use e-cigarettes when they stop using them for a week, while trying different types of nicotine patches to see how they help.

  Recruiting Early Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT06066996

• Text messaging program to help young adults quit e-cigarettes

  This study is testing if a text messaging program can help young adults in rural areas quit using e-cigarettes.

  Recruiting University of Wisconsin, Milwaukee · Milwaukee, Wisconsin · NCT05906082

• Long-term lung health impact of e-cigarette smoking

  This study is trying to see how using e-cigarettes affects lung health over five years in people aged 16 and older compared to those who have never smoked.

  Recruiting Western University, Canada · London, Ontario · NCT04616313

NIH-funded research (22)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Respiratory effects of metal and aldehyde exposure from e-cigarette use in young adults

  Young adults who use e-cigarettes may inhale metals and aldehydes that could affect their breathing and cause inflammation.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11415652

• Long-term effects of vaping on heart and lung health

  A long-term study will follow people who vape and non-vapers to see how vaping might influence heart and lung health over three years.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11378989

• Using Smart Machines to Understand How People Talk About Anti-E-Cigarette Campaigns on Social Media

  Researchers are testing new computer methods to see how people on Twitter and TikTok react to anti-vaping messages and the voices that oppose them.

  NIH research National Opinion Research Center · Chicago, United States · NIH-11367442

• How social media and cultural background shape e-cigarette use in Mexican American college students

  This project looks at whether exposure to e-cigarette content on platforms like TikTok and YouTube and a student's cultural background relate to vaping among Mexican American college students.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11311919

• E-cigarette use and emphysema risk in young adults (VapeScan)

  A study to understand whether vaping or traditional cigarettes cause early lung damage in young adults.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11298469

• How vaping affects teens' brains and thinking

  This project looks at whether using e-cigarettes (vaping) changes brain development and thinking skills in children and teenagers.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11257343

• Wearable sensor to track e-cigarette use in real time

  This project uses a small wearable sensor plus phone data and AI to track when and how young people use e-cigarettes.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11248430

• E-cigarette use and long-term heart and lung health

  This project looks at how regular e-cigarette use affects heart and lung health over several years.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11187128

• How e-cigarette metals and chemicals affect young adults' breathing

  This project measures metal and aldehyde exposure and signs of lung inflammation in young adults who do and do not use e-cigarettes.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11180392

• Investigating the respiratory effects of e-cigarette use in young adults

  This study is looking at how using e-cigarettes might impact the lung health of young adults by comparing those who use e-cigs to those who don’t, to see if there are any harmful effects from the chemicals in e-cigs.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11144631

• Understanding Social Media's Influence on E-cigarette Prevention Messages

  This project uses advanced computer tools to understand how social media platforms like Twitter and TikTok shape opinions about preventing e-cigarette use, especially among young people.

  NIH research National Opinion Research Center · Chicago, United States · NIH-11118916

• Effects of using both cigarettes and e-cigarettes on heart and lung health

  This study is looking at how using both regular cigarettes and new pod-style e-cigarettes affects heart and lung health, and it's designed to help us understand if using both together is riskier than using just one of them.

  NIH research Northeastern University · Boston, United States · NIH-11088886

• How social media influences e-cigarette use among Mexican American college students

  This study is looking at how seeing e-cigarette ads on social media affects Mexican American college students in South Texas and their use of e-cigarettes, while also considering how their cultural background plays a role.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11064065

• Tracking e-cigarette use in real time with wearable sensors

  This study is looking at how young people use e-cigarettes by using special sensors to track their habits in real time, so we can better understand their usage and help create better ways to prevent and stop e-cigarette use among youth.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11058061

• Effects of e-cigarette use on brain development in adolescents

  This study looks at how using e-cigarettes might change the way young people's brains work and develop, focusing on kids and teens aged 9 to 20, to help understand the risks of vaping compared to smoking regular cigarettes.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11055420

• Creating an online program to help young adults reduce e-cigarette use and smoking risk

  This study is creating a friendly online program for young adults aged 18-22 to help them cut down on e-cigarette use and avoid smoking by providing helpful information and support through their phones.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11031379

• Exploring how social media affects young adults' vaping habits

  This study is looking at how using social media affects young adults aged 18-25 who vape, to see if seeing vaping posts online changes their vaping habits and mental health, and it will help find ways to reduce any negative effects of social media on vaping.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11031368

• Investigating e-cigarette use trends among U.S. adolescents and young adults.

  This study looks at how young people in the U.S. use e-cigarettes over time and how it relates to smoking and other substances, helping us learn more about the health effects and what influences their choices.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10984467

• Effects of e-cigarette use on heart and lung health over time

  This study is looking at how using e-cigarettes for a long time affects heart and lung health, and it's for people who have been using e-cigarettes regularly, as well as some who don’t use any tobacco products at all.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10943297

• Impact of e-cigarette use on oral cancer risk

  This study looks at how using e-cigarettes, whether on their own or with regular cigarettes, might increase the risk of oral cancer by potentially harming DNA, and it's designed for anyone interested in understanding the health effects of vaping.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-10880263

• Detecting support and opposition to e-cigarette prevention messages on social media

  This study looks at how social media, like Twitter and TikTok, affects how people view campaigns aimed at preventing e-cigarette use, and it hopes to find ways to make these campaigns more effective by understanding what people think about them.

  NIH research National Opinion Research Center · Chicago, United States · NIH-10875443

• Understanding how social media marketing affects e-cigarette use among teens.

  This study looks at how social media marketing, especially from influencers, affects high school students' use of e-cigarettes by analyzing millions of posts on platforms like Instagram, YouTube, and TikTok to see what trends are out there and how they might influence young people's choices.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10675527

Related topics

Quick answers

How many E-cigarette Use clinical trials are recruiting right now?

14, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (10 trials), Thailand (2 trials), Canada (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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