How vaping affects teens' brains and thinking

Health Effects of E-cigarette Use on Brain Functions and Cognitive Development among Adolescents: A US Population-Based Study

NIH-funded research University of Nebraska Medical Center · NIH-11257343

This project looks at whether using e-cigarettes (vaping) changes brain development and thinking skills in children and teenagers.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Nebraska Medical Center NIH-funded
Lab location1 site (Omaha, United States)
Project IDNIH-11257343 on NIH RePORTER

What this research studies

If your child were included, researchers would look at brain scans and thinking tests that the ABCD study already collected from nearly 12,000 U.S. kids who were 9–10 at the start and were followed into their teens. They will compare children who vape, children who smoke cigarettes, and children who do not use nicotine to look for differences in brain structure and cognitive skills over time. The team will pay special attention to kids who only vape so they can separate nicotine effects from smoke exposure. The goal is to understand whether vaping during adolescence is linked to changes in brain maturation or thinking abilities.

Who could benefit from this research

Good fit: Ideal candidates are children and adolescents (roughly ages 9–18) who have used e-cigarettes, smoked cigarettes, or never used nicotine and who are part of the ABCD study or a similar U.S. cohort.

Not a fit: Adults outside the adolescent age range or people with brain conditions unrelated to nicotine exposure are unlikely to benefit directly from this work.

Why it matters

Potential benefit: If successful, the findings could help parents, clinicians, and regulators better protect young people by clarifying how vaping affects teen brain development.

How similar studies have performed: Animal studies show adolescent nicotine exposure can alter brain development, but human evidence specifically on vaping is limited and this analysis addresses a relatively untested question.

Where this research is happening

Omaha, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.