Impact of e-cigarette use on oral cancer risk
Official title: Biological impact of exclusive and dual e-cigarette use on oral cancer risk
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10880263 · Data updated 2026-11-12
This study looks at how using e-cigarettes, whether on their own or with regular cigarettes, might increase the risk of oral cancer by potentially harming DNA, and it's designed for anyone interested in understanding the health effects of vaping.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 15, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $358,738 |
| NIH project number | 5R01CA242168-05 |
| Project ID | NIH-10880263 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who use electronic cigarettes, either exclusively or in combination with traditional cigarettes.
✕Less likely to help
Patients who do not use electronic cigarettes or traditional tobacco products may not benefit from this research.
What this research studies
This research investigates how using electronic cigarettes, both exclusively and alongside traditional cigarettes, affects the risk of developing oral cancer. It focuses on understanding the genotoxic effects of e-cigarette aerosols, which contain harmful substances that may damage DNA and reduce the body's ability to repair it. By studying both exclusive and dual users, the research aims to uncover the potential health risks associated with e-cigarette use and inform public health policies. The methodology includes in vitro and animal model assessments to evaluate DNA damage and gene expression changes.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for oral cancer related to e-cigarette use.
How similar studies have gone: While there have been no prior genotoxic studies specifically in electronic cigarette users, related research has shown concerning effects of tobacco products on DNA damage.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Queimado, Lurdes — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Queimado, Lurdes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.