Condition

Vaping clinical trials and research

• 13Clinical trials
• 82NIH research projects
• 4Countries

Newest Vaping clinical trials

All recruiting trials (13)

• TUBSIS 2.0 — an online program to help adults reduce or quit smoking and vaping

  This program tests whether a free, anonymous, 4-week web-based course using mindfulness, self-compassion, and behavior-change techniques helps German-, English-, and Turkish-speaking adults who smoke or vape reduce or quit tobacco.

  Recruiting University of Zurich · Zurich · NCT07568483

• Social media support groups to help teens and young adults quit vaping

  This pilot tries a social-media group program called the Quit the Hit Toolkit to help adolescents and young adults who vape stop using nicotine.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07540780

• How synthetic nicotine and nicotine analogues behave in the body when vaped

  This study tests synthetic nicotine and related nicotine analogues in vapes to see how they move through and act in the body compared with regular nicotine.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07348224

• Varenicline plus enhanced TMS to help adults quit smoking and vaping

  This study tests whether adding active enhanced accelerated transcranial magnetic stimulation (aTMS) to varenicline helps adults 18–65 quit nicotine use more effectively than varenicline with sham stimulation.

  Recruiting Phase 4 Massachusetts General Hospital · Boston, Massachusetts · NCT07145866

• Varenicline to help adults stop vaping

  This trial tests whether the smoking-cessation pill varenicline helps adults who vape daily quit e-cigarettes.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT07040566

• Using tDCS (mild brain stimulation) to reduce vaping

  This project will try daily transcranial direct current stimulation (tDCS) to reduce cravings and vaping in adults who use nicotine e-cigarettes every day and are not planning to quit.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06885606

• Lung health in Canadians who use vaping devices

  This project will test new breathing tests, scans, and exercise measures to see if vaping harms the lungs of Canadian adolescents and adults.

  Recruiting at 5 sites University of British Columbia · Edmonton, Alberta and 7 other locations · NCT06819969

• Effects of non-invasive vagus nerve stimulation on cognition in young adult vapers

  This study is testing if a new type of stimulation can help improve thinking skills in young adults who vape.

  Recruiting Temple University · Philadelphia, Pennsylvania · NCT06804109

• QuitVaping behavioral program with texting support to help teens stop vaping

  This trial will try QuitVaping plus extra texting to see if it helps teens aged 14–18 who vape nicotine quit more than standard education and referral alone.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06765291

• Impact of e-cigarettes during pregnancy on children's health

  This study looks at how using e-cigarettes during pregnancy affects the health of children in their early years.

  Recruiting at 3 sites University College Dublin · Dublin and 2 other locations · NCT06297005

• Assessing lung and heart effects of vaping in adults

  This study is testing how vaping affects the lungs and heart in adults who use e-cigarettes over five years.

  Recruiting Laval University · Québec · NCT06291597

• How marijuana (THC) and tobacco interact when used together

  This test tries to see if combining marijuana (THC) and tobacco changes blood drug levels and how people feel and respond physically in adults who regularly use both.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT05999383

• Understanding how vaping affects blood vessels

  This study looks at how vaping affects the blood vessels of adults aged 18-40 by comparing current e-cigarette users to healthy people who have never smoked or vaped.

  Recruiting University of Miami · Miami, Florida · NCT05454267

NIH-funded research (newest 40 of 82)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Flavor rules and youth smoking/vaping: what happens when flavors are restricted

  A nationwide study will look at how banning or limiting flavored tobacco products affects how often adults and youth smoke or vape.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11421858

• Vaping cessation for teens using Kick-Nic! and a CBT app

  A Youth-focused program tests a CBT-based smartphone app and a virtual in-person CBT to help teens quit vaping.

  NIH research Yale University · New Haven, United States · NIH-11413484

• Social media groups help teens quit vaping

  A teen-focused program on Instagram direct message groups aims to help adolescents stop using e-cigarettes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11412591

• Parents Helping Parents: A Two-Arm Trial to Help Teens Quit Vaping

  A two-arm trial tests a parent-supported approach to help youths aged 15–18 quit vaping.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11401410

• How vaping prevention ads affect teens and young adults

  A nationwide project looks at which vaping-prevention video ads work best for teens and young adults and how they might reduce vaping when shown online.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11400544

• Motivation-based teen vaping profile to guide quitting help

  Aims to understand why adolescents vape and use that knowledge to tailor stopping tools that fit teens.

  NIH research University of Louisville · Louisville, United States · NIH-11399916

• AI-powered messages to help teens quit vaping on social media

  A teen-focused project using artificial intelligence to craft social media messages that discourage vaping among 13-year-olds and older youth.

  NIH research University of Rochester · Rochester, United States · NIH-11399825

• Remote, young adult-led help to quit vaping and prevent tobacco use among teens

  A youth-friendly behavioral and digital program led by remote lay counselors aims to help high school students quit vaping and prevent them from starting or escalating tobacco use.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11391375

• QuitQuest: a smartphone app to help teens stop vaping

  A teen-friendly app called QuitQuest to help adolescents stop using electronic nicotine delivery systems (ENDS) is being tested in a large randomized trial.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11389733

• How school and local vaping rules affect teens and adults

  Aiming to understand how school, state, and local vaping policies shape nicotine use and health outcomes across teens and adults.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11389421

• How vaping might weaken the lungs and raise infection risk

  This project explores whether vaping e-liquid makes the lung more prone to infections, using human lung cells and a mouse model to study immune responses.

  NIH research North Carolina Central University · Durham, United States · NIH-11377555

• Co-creating vaping prevention for urban Indigenous youth in the Southwest

  A community-led project partners with urban Indigenous communities to develop prevention messages and programs to reduce vaping among Indigenous teens and young adults.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11377106

• Preventing vaping escalation in teens with targeted messages

  A new NIH grant aims to test clear, teen-friendly messages designed to stop infrequent teen vapers from vaping more often.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11366078

• Understanding how vaping THC with or without nicotine affects how it works in the body

  This study looks at how smoking-vape devices deliver THC and how adding nicotine changes how THC acts in the body and its effects.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11365055

• Social Media Anti-vaping for Sexual and Gender Minority Teens

  This effort creates and shares anti-vaping content on social media specifically for lesbian, gay, bisexual, transgender, and queer teens to help them avoid or stop vaping.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11362786

• Which vaping-prevention videos help teens and young adults most?

  This project will find out which vaping-prevention video ads best help teens and young adults avoid or stop vaping.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11362775

• Vaping in Youth: How e-cigarettes affect thinking, behavior, and health

  This NIH grant looks at how e-cigarettes affect kids and teens and aims to find ways to reduce tobacco use and its harms.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11355472

• Differentiating vaping from smoking through epigenetic and transcriptomic markers

  This study looks at adults who vape or smoke to identify specific DNA methylation and gene expression changes that distinguish vaping from smoking, with the goal of finding biomarkers tied to health risks.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11348860

• Helping Parents Prevent Adolescent Vaping: A Longitudinal Study and Experimental Messages

  A study with 12-year-olds’ families aims to understand how parental knowledge and parenting practices influence teens’ nicotine and cannabis vaping, and tests messages to help parents prevent vaping.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11344769

• Youth vaping prevention using immersive VR to boost emotion regulation

  A school-based VR game helps 8th graders build emotion regulation skills to reduce vaping.

  NIH research Yale University · New Haven, United States · NIH-11332970

• Automatic detection of vaping puffing with a flexible e-cigarette monitor

  A small, low-cost sensor system called FRIENDS will be used to continuously track how people puff on their e-cigarettes in real life.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11332835

• Understanding and helping teens and young adults quit vaping

  A clinician-scientist is studying how to help teens and young adults quit using e-cigarettes and stay engaged with proven quit programs.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11332692

• Impact of Adolescent Vaping on Brain Health

  This research explores how vaping nicotine might affect the brain development of adolescents and young adults.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11326318

• Vaping in teens: how use develops and its impact on well‑being

  A youth-focused study looks at how vaping frequency and dependence form during high school and how it relates to healthy development and well‑being.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11326314

• MARVEL: Understanding Vaping Risks for Teens

  A program to understand how vaping affects teens and to create messages that help reduce vaping among adolescents.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11326312

• Chemicals released by vaping cannabis

  This work looks at which chemicals are produced when people vape concentrated cannabis and how different devices and formulations change those emissions, with special attention to risks for young users.

  NIH research Portland State University · Portland, United States · NIH-11324297

• How vaping changes newer nicotine chemicals in e-cigarettes

  This work looks at how using flavored e-cigarettes can change newer forms of nicotine, like 6‑methyl nicotine, and what that might mean for teens and young adults.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11309690

• ElevateAR: A digital AR tool to help teens quit vaping

  A youth-focused digital tool uses augmented reality to help teens and young adults ages 13–21 quit vaping.

  NIH research Ibis LLC · San Francisco, United States · NIH-11292687

• Perinatal nicotine exposure and asthma risk: how lung immune cells react

  This grant looks at how nicotine exposure before birth may change the lungs’ immune cells and raise the risk of allergic asthma in offspring.

  NIH research Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, United States · NIH-11277706

• REVIVE: Rural text messages to help young adults quit vaping

  A nationwide study tests a culturally tailored text-m messaging program to help rural young adults quit vaping nicotine.

  NIH research University of Wisconsin Milwaukee · Milwaukee, United States · NIH-11267777

• Vaping vitamin E acetate may create a new toxic chemical that causes fever and lung inflammation

  This work looks at whether heating vitamin E acetate in vaping devices forms a previously missed toxic compound that can cause fever and lung inflammation in people who vape.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11257340

• How vaping CBD and THC can affect your lungs

  This project looks at whether chemicals and contaminants in CBD and THC vaping liquids turn into reactive compounds that can harm airway cells.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11252576

• Avatar-led app using ACT to help young adults quit vaping

  This project offers an avatar-led smartphone program based on Acceptance and Commitment Therapy to help young adults stop using e-cigarettes.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11247482

• How vaping affects lung immunity and infection risk

  This work explores how e-cigarette use might weaken your lungs' defenses, making them more vulnerable to infections.

  NIH research North Carolina Central University · Durham, United States · NIH-11190785

• Instagram group program to help teens quit vaping

  This program uses Instagram direct-message groups to help teens and young adults (ages 13–21) stop using e-cigarettes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11189773

• Remote youth program with young-adult counselors and an app to help teens stop vaping and avoid cigarettes

  This program offers teens remote support from young-adult counselors plus a smartphone app to help them stop vaping and avoid starting cigarette smoking.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11187243

• Finding why teens vape to guide better quitting programs

  Researchers will identify different reasons teens use e-cigarettes to help design quitting programs for adolescents.

  NIH research University of Louisville · Louisville, United States · NIH-11182570

• Parent-to-parent support to help teens stop vaping

  A program that connects parents of teens who vape with other parents who have successfully helped their kids quit, aimed at teens about 15–18 years old.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11178626

• Help for teens to quit vaping with a smartphone app or virtual counseling

  This project compares a teen-focused quitting app called Kick‑Nic! with weekly virtual or in-person CBT to help 12–20-year-olds stop using e-cigarettes.

  NIH research Yale University · New Haven, United States · NIH-11177758

• Partnering with Indigenous Communities to Prevent Youth Vaping in the Southwest

  This project works with urban Indigenous communities in the Southwest to create new ways to help prevent young people from starting to vape nicotine and cannabis.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11172434

Related topics

Quick answers

How many Vaping clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (7 trials), Canada (3 trials), Switzerland (2 trials), Ireland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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