Effects of e-cigarette use on heart and lung health over time

Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health

['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10943297

This study is looking at how using e-cigarettes for a long time affects heart and lung health, and it's for people who have been using e-cigarettes regularly, as well as some who don’t use any tobacco products at all.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF WISCONSIN-MADISON (nih funded)
Locations1 site (MADISON, UNITED STATES)
Trial IDNIH-10943297 on ClinicalTrials.gov

What this research studies

This research investigates the long-term health effects of electronic nicotine delivery systems (ENDS), commonly known as e-cigarettes, on cardiovascular and pulmonary health. It aims to understand how factors such as the amount of e-cigarette use, age, body weight, and the use of other tobacco products influence health outcomes. The study will involve 400 long-term e-cigarette users and 200 control participants who do not use e-cigarettes or combustible cigarettes, with comprehensive health assessments conducted over 36 months. These assessments will include various biomarkers related to heart and lung health, as well as measurements of arterial structure and nervous system activity.

Who could benefit from this research

Good fit: Ideal candidates for this research are long-term users of e-cigarettes who are stable in their usage patterns.

Not a fit: Patients who do not use e-cigarettes or combustible cigarettes will not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide valuable insights into the health risks associated with long-term e-cigarette use, potentially guiding public health recommendations and individual choices.

How similar studies have performed: While there is ongoing research into the effects of e-cigarettes, this study aims to provide novel insights into their long-term health impacts, making it a significant addition to the existing body of knowledge.

Where this research is happening

MADISON, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.