Effects of using both cigarettes and e-cigarettes on heart and lung health

Cardiopulmonary outcomes of dual cigarette and e-cigarette use in animal models of chronic exposure

['FUNDING_R01'] · NORTHEASTERN UNIVERSITY · NIH-11088886

This study is looking at how using both regular cigarettes and new pod-style e-cigarettes affects heart and lung health, and it's designed to help us understand if using both together is riskier than using just one of them.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorNORTHEASTERN UNIVERSITY (nih funded)
Locations1 site (BOSTON, UNITED STATES)
Trial IDNIH-11088886 on ClinicalTrials.gov

What this research studies

This research investigates the health impacts of using both traditional cigarettes and new pod-style e-cigarettes on the heart and lungs. By using animal models, specifically mice, the study will expose them to different combinations of cigarette smoke and e-cigarette aerosols to observe how these substances affect cardiovascular and respiratory systems. The goal is to understand whether dual use of these products leads to greater health risks compared to using either one alone. This research aims to provide critical data that could inform future regulations on e-cigarettes.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals over 21 years old who are current smokers or dual users of cigarettes and e-cigarettes.

Not a fit: Patients who do not use tobacco products or e-cigarettes will not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better understanding and regulations regarding the health risks associated with dual use of cigarettes and e-cigarettes.

How similar studies have performed: While the health impacts of traditional cigarette smoking are well-documented, the specific effects of dual use with e-cigarettes are still being explored, making this research a novel investigation.

Where this research is happening

BOSTON, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.