E-cigarette use and long-term heart and lung health
Official title: Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health
Funded at University of Wisconsin-Madison · NIH-11187128 · Data updated 2026-11-12
This project looks at how regular e-cigarette use affects heart and lung health over several years.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 6, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,287,821 |
| NIH project number | 5R01HL175602-02 |
| Project ID | NIH-11187128 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults who have been long-term, stable users of e-cigarettes or age- and sex-matched adults who do not use e-cigarettes or combustible cigarettes.
✕Less likely to help
People who currently smoke combustible cigarettes, who have only tried e-cigarettes briefly, or who cannot attend repeated clinic visits may not be eligible or receive direct benefit from participating.
What this research studies
If you join, researchers will follow people who regularly use e-cigarettes and a group of matched non-users for 36 months and collect health measurements over time. Participants will have vital sign checks, fasting blood draws to measure inflammation, oxidative stress, lipids, and metabolic markers, and imaging tests like carotid ultrasound plus artery function tests. The team will also measure heart rate variability and track how heavy your e-cigarette use is, your age and body weight, and whether you use other products. The project aims to describe long-term use patterns, dependence, and biological signs linked to cardiovascular and lung health.
Why it matters
Potential benefit: Results could help people understand whether long-term e-cigarette use changes the risk of heart and lung disease and guide safer choices and policies.
How similar studies have gone: Short-term studies show lower carcinogen exposure with e-cigarettes than with smoking, but long-term effects on cardiovascular and pulmonary disease remain largely unknown.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Baker, Timothy B — University of Wisconsin-Madison
- Study coordinator: Baker, Timothy B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.