Long-term effects of vaping on heart and lung health
Official title: Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health
Funded at University of Wisconsin-Madison · NIH-11378989 · Data updated 2026-11-12
A long-term study will follow people who vape and non-vapers to see how vaping might influence heart and lung health over three years.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 6, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,195,060 |
| NIH project number | 5R01HL175602-03 |
| Project ID | NIH-11378989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who are long-term, stable e-cigarette users and adults who do not use ENDS or combustible cigarettes, matched by age and gender.
✕Less likely to help
Individuals who do not use e-cigarettes or tobacco products and are not at risk for cardiovascular or pulmonary issues may have limited direct benefit.
What this research studies
This study will enroll 400 long-term e-cigarette users and 200 matched non-users to track cardiovascular and lung health biomarkers over 36 months. Researchers will measure blood markers of inflammation and metabolic health, along with imaging and functional tests of arteries and autonomic nervous system activity. Data will be analyzed to understand how vaping duration, age, body weight, and co-use of other products affect risk signals. The goal is to clarify potential long-term health implications of ENDS use for patients and clinicians making informed choices about vaping.
Why it matters
Potential benefit: If successful, the findings could help patients understand their long-term cardiovascular and lung health risks related to vaping and guide healthcare decisions.
How similar studies have gone: Previous research has begun to explore biomarkers in ENDS users, but this study's long follow-up and comprehensive biomarker panel are relatively unique.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Baker, Timothy B — University of Wisconsin-Madison
- Study coordinator: Baker, Timothy B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.