Long-term lung health impact of e-cigarette smoking

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This longitudinal study investigates the long-term effects of e-cigarette smoking on lung health over a period of five years. Participants aged 16 and older with a history of e-cigarette use will be monitored using advanced imaging techniques, including hyperpolarized xenon-129 MRI, alongside pulmonary function tests and exercise capacity assessments. The study will compare these participants with asymptomatic controls who have never smoked e-cigarettes or cigarettes. Data will be collected at multiple time points to evaluate changes in lung function and structure. The study aims to provide insights into the chronic effects of e-cigarette use on pulmonary health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.
* Male and female participant age ≥16 years.
* Participant has recently started vaping, \>1 and \<5 years weekly use.
* 70 participants will be c-cigarette never users.
* 70 participants will be former or current c-cigarette users.
* 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls.

Exclusion Criteria:

* Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia.
* Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material.
* Participant unable to perform spirometry or plethysmography maneuvers.

Where it's running

• Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
  London, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Grace E Parraga — Western University - Robarts Research Institute
• Study coordinator: Grace E Parraga, PhD
• Email: gparraga@robarts.ca
• Phone: 519-931-5265

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.