Exploring the role of skin bacteria in diabetic skin conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects skin swab samples from both diabetic and non-diabetic patients at Nanfang Hospital to analyze the skin microbiome's structure and function. By employing advanced omics technologies, the study aims to identify differences in skin flora among diabetic patients at varying risk levels for developing diabetic foot ulcers. Participants will be followed up to assess the incidence of ulcers, and discarded skin tissues from surgeries will be examined for pathological changes. The ultimate goal is to uncover mechanisms that could lead to early screening and prevention strategies for diabetic foot complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1\. Surface skin cotton swab collection

(1) Observation group: In the endocrinology department of Nanfang hospital, the patient were diagnosed with type 2 diabetes to the WHO 1999 diagnostic criteria for diabetes.

(2) Control group:

1. Control subjects that was ruled out diabetes according to the WHO 1999 diagnostic criteria for euglycemia.
2. Age ≥18 years, the patient and (or) his family members know and agree to participate in this study.

2\. Skin tissue collection

(1) Observation group:

1. The patient was diagnosed with type 2 diabetes in the Endocrinology Department, Burns Department, Traumatology Orthopedics, Plastic Surgery in Nanfang hospital.
2. Patients who need surgical operations such as debridement and amputation below the knee joint due to various reasons such as diabetic foot osteomyelitis, fractures, car accidents and so on.

(2) Control group:

1. The patient without type 2 diabetes in the Endocrinology Department, Burns Department, Traumatology Orthopedics, Plastic Surgery in Nanfang hospital.
2. Patients who need surgical operations such as debridement and amputation below the knee joint due to various reasons such as post-traumatic foot osteomyelitis, fractures, car accidents and so on.
3. Age ≥18 years, the patient and (or) his family members know and agree to participate in this study.

Exclusion Criteria:

The patients Including other skin diseases, using medically prescribed soap for bathing, using cosmetics on the feet, suffering from severe liver and kidney disease, immune system disease, HIV infection, malignant tumors, or using immunosuppressive drugs within the first four weeks. The patient or (and) their family members refused to participate in this study.

The researchers judged that they are not suitable to participate in this research.

Where it's running

• Nanfang Hospital
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Xiaoyan Tan
• Email: nfyykyc@163.com
• Phone: 02062786842

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Miro3D Wound Matrix for Diabetic Foot Ulcers

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• Non-invasive imaging to measure skin composition and structure

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  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06976073

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.